产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
WAVE3(Scar3)
目录 :
W0952-01
规格 :
100微升
价格 :
516美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
W0952-01
Product wo Prefix :
WAVE3(Scar3)
宿主 :
兔
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
100微升
Size1 List :
516美元
抗体亚型 :
IgG
Desc1 :
Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neuronal defects and embryonic lethality (2,3). Loss of WASP results in immune system defects and fewer immune cells (4). WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain (5). WAVE-3 may act as a tumor suppressor in neuroblastoma, a childhood disease of the sympathetic nervous system (6). Increased expression of WAVE-3 is seen in breast cancer, and studies in breast adenocarcinoma cells indicate that WAVE-3 regulates breast cancer progression, invasion and metastasis through the p38 mitogen-activated protein kinase (MAPK) pathway (7,8).
Applications:
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended Dilution:
Western Blot: 1:1000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Calc Crossreactivity :
Hu Mk Mo Rt
免疫原 :
Synthetic peptide corresponding to the central sequence of human WAVE-3.
特异性 :
Detects endogenous levels of total human WAVE-3 protein. The antibody does not cross-react with WAVE-1 or WAVE-2. Species Crossreactivity: mouse, monkey and rat
纯度 :
Supernatant.
形式 :
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
浓度 :
未确定
Desc2 :
Product Type: Pab
Isotype: IgG
Host: rabbit
Source: human
Concentration: Not determined
Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity: Supernatant.
Immunogen: Synthetic peptide corresponding to the central sequence of human WAVE-3.
Specificity: Detects endogenous levels of total human WAVE-3 protein. The antibody does not cross-react with WAVE-1 or WAVE-2. Species Crossreactivity: mouse, monkey and rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
免疫沉淀免疫印迹
储存温度 :
-20°C
参考文献 :
1. Millard, T.H. et al. (2004) Biochem J. 380, 1-17. 2. Yan, C. et al. (2003) EMBO J. 22, 3602-3612. 3. Snapper, S.B. et al. (2001) Nat. Cell Biol. 3, 897-904. 4. Zhang, J. et al. (1999) J. Exp. Med. 190, 1329-4132. 5. Suetsugu, S. et al. (1999) Biochem. Biophys. Res. Commun. 260, 296-302. 6. Sossey-Alaoui, K. et al. (2002) Oncogene 21, 5967-5974. 7. Sossey-Alaoui, K. et al. (2005) Exp. Cell Res. 308, 135-145. 8. Sossey-Alaoui, K. et al. (2007) Am. J. Pathol. [Epub ahead of print]
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/14/W0952-01_1.jpg
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/12.png)
US Biological
4 Technology Way
Salem, MA01970
Salem, MA01970
tech@usbio.net
https://www.usbio.net800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。
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