产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
USP7, ID (USP7, HAUSP, Ubiquitin Carboxyl-terminal Hydrolase 7, Deubiquitinating Enzyme 7, Herpes Virus-associated Ubiquitin-specific Protease, Ubiquitin Thioesterase 7, Ubiquitin-specific-processing Protease 7)
目录 :
043678
规格 :
200微升
价格 :
569美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
043678
Product wo Prefix :
USP7, ID (USP7, HAUSP, Ubiquitin Carboxyl-terminal Hydrolase 7, Deubiquitinating Enzyme 7, Herpes Virus-associated Ubiquitin-specific Protease, Ubiquitin Thioesterase 7, Ubiquitin-specific-processing Protease 7)
宿主 :
兔
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
200微升
Size1 List :
569美元
抗体亚型 :
IgG
Desc1 :
Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the Herpes virus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
Applications:
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
又名 :
USP7, HAUSP, Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
免疫原 :
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 320-348 in the central region of human USP7. Species sequence homology: rat
特异性 :
识别人类USP7
纯度 :
Purified by Protein A and peptide affinity chromatography.
形式 :
以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠
浓度 :
As reported
Desc2 :
Product Type: Pab
Isotype: IgG
Host: rabbit
Source: human
Concentration: As reported
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity: Purified by Protein A and peptide affinity chromatography.
Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 320-348 in the central region of human USP7. Species sequence homology: rat
Specificity: Recognizes human USP7.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E免疫印迹
储存温度 :
-20°C
参考文献 :
1. Sarkari, F., et al., J. Mol. Biol. 402(5): 825-837 (2010). 2. de Bie, P., et al., Biochem. Biophys. Res. Commun. 400(3): 389-395 (2010). 3. Maertens, G.N., et al., EMBO J. 29(15): 2553-2565 (2010). 4. Rose, J.E., et al., Mol. Med. 16(7-8): 247-253 (2010). 5. Tang, J., et al., Biochem. Biophys. Res. Commun. 393(3): 542-545 (2010).
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/32/043678_1.jpg
更多信息或购买 :
公司信息
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US Biological
4 Technology Way
Salem, MA01970
Salem, MA01970
tech@usbio.net
https://www.usbio.net800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。
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