抗体

COCH, ID (COCH, COCH5B2, Cochlin, COCH-5B2)

034071

200微升

569美元

多克隆

domestic rabbit

未共轭

COCH, ID (COCH, COCH5B2, Cochlin, COCH-5B2)

兔

多克隆抗体

抗体

200微升

569美元

IgG

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq]. Applications: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry and ELISA. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (FFPE): 1:10-1:50 Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

COCH, COCH5B2, Cochlin, COCH-5B2

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 399-428 in the central region of human COCH, UniProt Accession #NP_004077.1; NP_001128530.1; O43405; ; O5EA64.

Recognizes human COCH. Species Sequence Homology: bovine

Purified by Protein A affinity chromatography.

以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠

As Reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 399-428 in the central region of human COCH, UniProt Accession #NP_004077.1; NP_001128530.1; O43405; ; O5EA64. Specificity: Recognizes human COCH. Species Sequence Homology: bovine Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E FC免疫组化免疫印迹

-20°C

1. Ikezono, T., et al. Acta Otolaryngol. 130(8):881-887 (2010) 2. Yao, J., et al. J. Biol. Chem. 285(20):14909-14919 (2010) 3. Baek, J.I., et al. Clin. Genet. 77(4):399-403 (2010) 4. Davila, S., et al. Genes Immun. 11(3):232-238 (2010) 5. Lee, E.S., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2060-2066 (2010)

https://usbio-images.r.worldssl.net/prodimages/17/034071_1.jpg