产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
DDR1-IN-1 dihydrochloride
目录 :
5077/10
规格 :
10 mg (also 50 mg)
价格 :
289美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 6
参考文献
Rauner G, Jin D, Miller D, Gierahn T, Li C, Sokol E, et al. Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1. Nat Commun. 2021;12:7116 pubmed 出版商
Romayor I, Badiola I, Benedicto A, Marquez J, Herrero A, Arteta B, et al. Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. Sci Rep. 2020;10:18398 pubmed 出版商
Lino M, Ngai D, Liu A, Mohabeer A, Harper C, Caruso L, et al. Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease. Mol Metab. 2020;39:101006 pubmed 出版商
Vehlow A, Klapproth E, Jin S, Hannen R, Hauswald M, Bartsch J, et al. Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity. Cell Rep. 2019;26:3672-3683.e7 pubmed 出版商
Mogami H, Kishore A, Word R. Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. Sci Rep. 2018;8:696 pubmed 出版商
Malaguarnera R, Nicolosi M, Sacco A, Morcavallo A, Vella V, Voci C, et al. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget. 2015;6:16084-105 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
5077
SKU号 :
5077/10
产品名称 :
DDR1-IN-1 dihydrochloride
描述 :
Selective DDR1 inhibitor
靶标 :
Additional RTK Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
625.51
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.
extended description :
Selective DDR1 inhibitor
化学品名文本 :
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
配方 :
C 30 H 31 F 3 N 4 O 3。 2HCl
配方文本 :
C30H31F3N4O3.2HCl
cas num :
1780303-76-5
美元 :
289美元
产品细节 :
Selective DDR1 inhibitor
储存 :
Desiccate at RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国