产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
8-pCPT-2-O-Me-cAMP-AM
目录 :
4853/100U
规格 :
100微克
价格 :
257美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 10
参考文献
Gao N, Raduka A, Rezaee F. Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin. J Cell Sci. 2022;135: pubmed 出版商
Goode D, Molliver D. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021;41:2883-2898 pubmed 出版商
Narayanan V, Schappell L, Mayer C, Duke A, Armiger T, Arsenovic P, et al. Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis. Curr Biol. 2020;30:624-633.e4 pubmed 出版商
Kayhan M, Koyas A, Akdemir I, Savas A, Cekic C. Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol. 2019;203:3247-3255 pubmed 出版商
Goode D, Molliver D. Phospho-substrate profiling of Epac-dependent protein kinase C activity. Mol Cell Biochem. 2019;456:167-178 pubmed 出版商
Mayati A, Moreau A, Le Vee M, Bruyère A, Jouan E, Denizot C, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018;8:16115 pubmed 出版商
Kumar N, Prasad P, Jash E, Jayasundar S, Singh I, Alam N, et al. cAMP regulated EPAC1 supports microvascular density, angiogenic and metastatic properties in a model of triple negative breast cancer. Carcinogenesis. 2018;39:1245-1253 pubmed 出版商
Mishra R, Belder N, Ansari S, Kayhan M, Bal H, Raza U, et al. Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer. Clin Cancer Res. 2018;24:1987-2001 pubmed 出版商
Ramos C, Lin C, Liu X, Antonetti D. The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. J Biol Chem. 2018;293:717-730 pubmed 出版商
Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, et al. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 2015;212:1021-41 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
4853
SKU号 :
4853/100U
产品名称 :
8-pCPT-2-O-Me-cAMP-AM
描述 :
Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
靶标 :
EPAC Activators
类别 :
Small Molecules
单位尺寸 :
100微克
纯度 :
97%
观察到的分子量 :
557.9
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. Stimulates insulin secretion in rat INS-1 cells. More potent, cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645). . This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.
extended description :
Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
化学品名文本 :
8-(4-Chlorophenylthio)-2 -O-methyladenosine-3 ,5 -cyclic monophosphate acetoxymethyl ester
配方 :
C 20 H 21 ClN 5 O 8 PS
配方文本 :
C20H21ClN5O8PS
cas num :
1152197-23-3
美元 :
257美元
产品细节 :
Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645)
别名 :
007-艾姆斯氏试验
储存 :
存放在-20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国