产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
阿霉素盐酸盐
目录 :
2252/10
规格 :
10 mg (also 50 mg)
价格 :
202美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 28
参考文献
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Guillon J, Petit C, Moreau M, Toutain B, Henry C, Roche H, et al. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis. 2019;10:199 pubmed 出版商
Yoon M, Kang S, Lee S, Woo T, Oh A, Park S, et al. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 2019;10:107 pubmed 出版商
Kanchanapally R, Deshmukh S, Chavva S, Tyagi N, Srivastava S, Patel G, et al. Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis. Int J Nanomedicine. 2019;14:531-541 pubmed 出版商
Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, et al. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun. 2018;9:1994 pubmed 出版商
Le Duff M, Gouju J, Jonchère B, Guillon J, Toutain B, Boissard A, et al. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis. 2018;9:199 pubmed 出版商
Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan A, et al. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer. 2017;17:803 pubmed 出版商
El Zawily A, McEwen E, Toosi B, Vizeacoumar F, Freywald T, Vizeacoumar F, et al. The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment. Sci Rep. 2017;7:14767 pubmed 出版商
Ayoub N, Al Shami K, Alqudah M, Mhaidat N. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents. Onco Targets Ther. 2017;10:4869-4883 pubmed 出版商
Gallagher L, Radhi O, Abdullah M, McCluskey A, Boyd M, Chan E. Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Cell Death Dis. 2017;8:e3014 pubmed 出版商
Tavangar F, Sepehri H, Saghaeian Jazi M, Asadi J. Amphotericin B potentiates the anticancer activity of doxorubicin on the MCF-7 breast cancer cells. J Chem Biol. 2017;10:143-150 pubmed 出版商
Beak J, Huang W, Parker J, Hicks S, Patterson C, Simpson P, et al. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017;2:39-53 pubmed 出版商
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed 出版商
Montgomery M, Chan T, Swigart P, Myagmar B, Dash R, Simpson P. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. PLoS ONE. 2017;12:e0168409 pubmed 出版商
Thomas R, Singh A, Cowley P, Myagmar B, Montgomery M, Swigart P, et al. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016;1:155-167 pubmed
Thomas R, Cowley P, Singh A, Myagmar B, Swigart P, Baker A, et al. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS ONE. 2016;11:e0155238 pubmed 出版商
Aho J, Helenius M, Vattulainen Collanus S, Alastalo T, Koskenvuo J. Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal. 2016;12:575-81 pubmed 出版商
Bussey K, Bapat A, Linnehan C, Wandoloski M, Dastrup E, Rogers E, et al. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. Clin Transl Med. 2016;5:1 pubmed 出版商
Hayano M, Yang W, Corn C, Pagano N, Stockwell B. Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ. 2016;23:270-8 pubmed 出版商
Zhitomirsky B, Assaraf Y. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance. Oncotarget. 2015;6:1143-56 pubmed
Smyth T, Kullberg M, Malik N, Smith Jones P, Graner M, Anchordoquy T. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release. 2015;199:145-55 pubmed 出版商
Sundaresan V, Menon J, Rahimi M, Nguyen K, Wadajkar A. Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications. Int J Pharm. 2014;466:1-7 pubmed 出版商
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Gharanei M, Hussain A, Janneh O, Maddock H. Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. PLoS ONE. 2013;8:e77713 pubmed 出版商
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Lim Y, Park T, Lim I. B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage. J Biol Chem. 2008;283:33110-8 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2252
SKU号 :
2252/10
产品名称 :
阿霉素盐酸盐
靶标 :
DNA Topoisomerase Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
579.99
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin (Cat. No. 1467) that is naturally fluorescent. Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II. It is a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Doxorubicin reduces intracellular tau levels. Doxorubicin also promotes formation of free radicals for the disruption of membrane lipids and DNA strands. Doxorubicin fluorescence is quenched upon intercalation into the DNA; while binding to histones or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles, increases Doxorubicin fluorescence. Doxorubicin fluorescence enables the monitoring of the localization of the drug within lipid bilayers and liposomal delivery systems and interaction of the drug with DNA and other macromolecules, as well as drug efflux pump activities.
extended description :
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
化学品名文本 :
10-[(3-Amino-2,3,6-trideoxy- -L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
配方 :
C 27 H 29 NO 11。 氯化氢
配方文本 :
C27H29NO11.氯化氢
cas num :
25316-40-9
美元 :
202美元
产品细节 :
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
别名 :
Adriamycin, NSC 123127
储存 :
Desiccate at RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国