产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
8-CPT-2Me-cAMP, 钠盐
目录 :
1645/1
规格 :
1毫克
价格 :
243美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 11
参考文献
Ng P, McIntosh K, Hargrave G, Ho K, Paul A, Plevin R. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal. 2018;51:59-71 pubmed 出版商
Mohan S, Narumiya S, Doré S. Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Neurotoxicology. 2015;46:53-9 pubmed 出版商
Hutchison M, White P. Prostacyclin regulates bone growth via the Epac/Rap1 pathway. Endocrinology. 2015;156:499-510 pubmed 出版商
Guichard A, Cruz Moreno B, Cruz Moreno B, Aguilar B, van Sorge N, Kuang J, et al. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013;14:294-305 pubmed 出版商
Garcia Murillas I, Sharpe R, Pearson A, Campbell J, Natrajan R, Ashworth A, et al. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene. 2014;33:2478-86 pubmed 出版商
Hu F, Ren J, Zhang J, Zhong W, Luo M. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A. 2012;109:17681-6 pubmed 出版商
Meitzen J, Luoma J, Stern C, Mermelstein P. ?1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem. 2011;116:984-95 pubmed 出版商
Himer L, Csóka B, Selmeczy Z, Koscsó B, Pócza T, Pacher P, et al. Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J. 2010;24:2631-40 pubmed 出版商
Soltoff S, Hedden L. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem. 2010;285:13337-48 pubmed 出版商
Scheibner K, Boodoo S, Collins S, Black K, Chan Li Y, Zarek P, et al. The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Am J Respir Cell Mol Biol. 2009;40:251-9 pubmed 出版商
Jeong H, Li Z, Brown M, Sacks D. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem. 2007;282:20752-62 pubmed
产品信息
品牌 :
Tocris
MasterCode :
1645
SKU号 :
1645/1
产品名称 :
8-CPT-2Me-cAMP, 钠盐
靶标 :
EPAC Activators
类别 :
Small Molecules
单位尺寸 :
1毫克
纯度 :
99%
观察到的分子量 :
507.82
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 M), but not PKA (EC50 10 M). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic -cells in vitro . Cell permeable analog (Cat. No. 4853) also available.
extended description :
Selective Epac activator
化学品名文本 :
8-(4-Chlorophenylthio)-2 -O-methyladenosine-3 ,5 -cyclic monophosphate sodium salt
配方 :
C 17 H 16 ClN 5 O 6 PS.Na
配方文本 :
C17H16ClN5O6PS.Na
cas num :
634207-53-7
美元 :
243美元
产品细节 :
Selective Epac activator
储存 :
存放在-20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国