产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Purvalanol B
目录 :
1581/10
规格 :
10 mg (also 50 mg)
价格 :
272美元
更多信息或购买 :
文章摘录数: 3
| 参考文献 |
|---|
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Keri G, et al. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics. 2007;6:537-47 pubmed
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产品信息
品牌 :
Tocris
MasterCode :
1581
SKU号 :
1581/10
产品名称 :
Purvalanol B
靶标 :
Cyclin-dependent Kinase Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
432.91
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).
extended description :
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
化学品名文本 :
(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
配方 :
C 20 H 25 ClN 6 O 3
配方文本 :
C20H25ClN6O3
cas num :
212844-54-7
美元 :
272美元
产品细节 :
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
别名 :
NG 95
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
公司总部: 英国