产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
KN-62
目录 :
1277/1
规格 :
1毫克
价格 :
202美元
更多信息或购买 :
文章摘录数: 28
参考文献
Sahu B, Rodriguez P, Nguyen M, Han R, Cero C, Razzoli M, et al. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep. 2019;28:2567-2580.e6 pubmed 出版商
Livingstone R, Elder M, Barrett M, Westlake C, Peppercorn K, Tate W, et al. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci. 2019;12:198 pubmed 出版商
Mauger O, Lemoine F, Scheiffele P. Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity. Neuron. 2016;92:1266-1278 pubmed 出版商
Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, et al. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. elife. 2016;5:e13185 pubmed 出版商
Qu M, Ji W, Zhao T, Fang C, Mao S, Gao Z. Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine. World J Gastrointest Pathophysiol. 2016;7:150-9 pubmed 出版商
Giannuzzo A, Pedersen S, Novak I. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Mol Cancer. 2015;14:203 pubmed 出版商
Heo S, Thorpe S, Driscoll T, Duncan R, Lee D, Mauck R. Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep. 2015;5:16895 pubmed 出版商
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed 出版商
Merino B, Quesada I, Hernández Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed 出版商
Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, et al. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016;213:456-64 pubmed 出版商
Galván E, Pérez Rosello T, Gómez Lira G, Lara E, Gutiérrez R, Barrionuevo G. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons. Neuroscience. 2015;290:332-45 pubmed 出版商
Ishii K, Sugimura Y. Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug. J Chem Biol. 2015;8:5-9 pubmed 出版商
Araki Y, Zeng M, Zhang M, Huganir R. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. Neuron. 2015;85:173-89 pubmed 出版商
Oh W, Parajuli L, Zito K. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons. Cell Rep. 2015;10:162-9 pubmed 出版商
Braganhol E, Kukulski F, Lévesque S, Fausther M, Lavoie E, Zanotto Filho A, et al. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta. 2015;1852:120-30 pubmed 出版商
Liu M, Zhuo M. Loss of long-term depression in the insular cortex after tail amputation in adult mice. Mol Pain. 2014;10:1 pubmed 出版商
Finsterwald C, Carrard A, Martin J. Role of salt-inducible kinase 1 in the activation of MEF2-dependent transcription by BDNF. PLoS ONE. 2013;8:e54545 pubmed 出版商
Trabanelli S, Ocadlikova D, Gulinelli S, Curti A, Salvestrini V, Vieira R, et al. Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol. 2012;189:1303-10 pubmed 出版商
Guo Y, Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 2012;318:2004-13 pubmed 出版商
Mockett B, Guevremont D, Wutte M, Hulme S, Williams J, Abraham W. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. J Neurosci. 2011;31:7380-91 pubmed 出版商
George A, MacLeod G, Zakon H. Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus. J Neurophysiol. 2011;106:319-31 pubmed 出版商
Person A, Raman I. Deactivation of L-type Ca current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei. Neuron. 2010;66:550-9 pubmed 出版商
Kobayashi T, Kouzaki H, Kita H. Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP. J Immunol. 2010;184:6350-8 pubmed 出版商
Bodhinathan K, Kumar A, Foster T. Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II. J Neurosci. 2010;30:1914-24 pubmed 出版商
Donnelly Roberts D, Namovic M, Han P, Jarvis M. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol. 2009;157:1203-14 pubmed 出版商
Diaz Hernandez M, del Puerto A, Díaz Hernández J, Diez Zaera M, Lucas J, Garrido J, et al. Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons. J Cell Sci. 2008;121:3717-28 pubmed 出版商
Coba M, Valor L, Kopanitsa M, Afinowi N, Grant S. Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus. J Biol Chem. 2008;283:34101-7 pubmed 出版商
Hu H, Xiao R, Wang C, Gao N, Colton C, Wood J, et al. Potentiation of TRPV3 channel function by unsaturated fatty acids. J Cell Physiol. 2006;208:201-12 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1277
SKU号 :
1277/1
产品名称 :
KN-62
描述 :
Non-competitive P2X7 antagonist
靶标 :
P2X Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
1毫克
纯度 :
98%
观察到的分子量 :
721.84
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
KN-62 is a selective, cell-permeable inhibitor of CaM kinase II (IC50 = 0.9 u M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
extended description :
Non-competitive P2X7 antagonist
化学品名文本 :
4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester
配方 :
C 38 H 35 N 5 O 6秒2
配方文本 :
C38H35N5O6S2
cas num :
127191-97-3
美元 :
202美元
产品细节 :
Non-competitive P2X7 antagonist
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国