产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
DL-TBOA
目录 :
1223/10
规格 :
10 mg (also 50 mg)
价格 :
277美元
更多信息或购买 :
文章摘录数: 57
参考文献
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Vance K, Rogers R, Hermann G. PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors. J Neurosci. 2015;35:776-85 pubmed 出版商
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Yang C, Huang C, Hsu K. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Neurosci. 2005;25:4288-93 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
1223
SKU号 :
1223/10
产品名称 :
DL-TBOA
描述 :
Selective non-transportable inhibitor of EAATs
靶标 :
Glutamate (EAAT) Transporter Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
239.23
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 6 M, 6 M and 70 M, for EAAT2, EAAT3 and EAAT1, respectively). DL-TBOA also inhibits EAAT4 and EAAT5 (Ki values are 4.4 M and 3.2 M respectively). DL-TBOA displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT2, EAAT1 and EAAT3, Ki values are 2.2, 2.9, and 9.3 M, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values are 0.59, 1.8 and 2.8 M for human EAAT2, EAAT3 and EAAT1, respectively. DL-TBOA augments SN 38 (Cat. No. 2684) induced colorectal cancer cell death in drug-resistant cell lines. DL-TBOA enhances synaptic activity in the frog labyrinth.
extended description :
Selective non-transportable inhibitor of EAATs
化学品名文本 :
DL-threo- -Benzyloxyaspartic acid
配方 :
C 11 H 13 NO 5
配方文本 :
C11H13NO5
cas num :
205309-81-5
美元 :
277美元
产品细节 :
Selective non-transportable inhibitor of EAATs
储存 :
Desiccate at -20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国