产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
PPADS tetrasodium salt
目录 :
0625/10
规格 :
10 mg (also 50 mg)
价格 :
97美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 22
参考文献
McEwan T, Sophocleous R, Cuthbertson P, Mansfield K, Sanderson Smith M, Sluyter R. Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation. Life Sci. 2021;283:119850 pubmed 出版商
Cuthbertson P, Geraghty N, Adhikary S, Casolin S, Watson D, Sluyter R. P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model. Clin Sci (Lond). 2021;135:495-513 pubmed 出版商
Cruz A, Beall C. Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance. Front Physiol. 2020;11:567378 pubmed 出版商
Coddou C, Sandoval R, Hevia M, Stojilkovic S. Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor. Neurosci Lett. 2019;690:219-224 pubmed 出版商
Conley J, Radhakrishnan S, Valentino S, Tantama M. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor. PLoS ONE. 2017;12:e0187481 pubmed 出版商
Yamashita T, Yamamoto S, Zhang J, Kometani M, Tomiyama D, Kohno K, et al. Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury. PLoS ONE. 2016;11:e0165189 pubmed 出版商
Zhang P, Zhang G, Zhou W, Weng S, Yang X, Zhong Y. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells. Sci Rep. 2016;6:28938 pubmed 出版商
Pozner A, Xu B, Palumbos S, Gee J, Tvrdik P, Capecchi M. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci. 2015;8:12 pubmed 出版商
Cheung K, Marques da Silva C, Vairo L, dos Santos D, Goldenberg R, Coutinho Silva R, et al. Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes. Purinergic Signal. 2015;11:127-38 pubmed 出版商
Fonseca B, Martínez Águila A, Díaz Hernández M, Pintor J. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal. 2015;11:87-93 pubmed 出版商
Bulavina L, Szulzewsky F, Rocha A, Krabbe G, Robson S, Matyash V, et al. NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal. 2013;9:199-205 pubmed 出版商
Ievglevskyi O, Palygin O, Kondratskaya E, Grebenyuk S, Krishtal O. Modulation of ATP-induced LTP by cannabinoid receptors in rat hippocampus. Purinergic Signal. 2012;8:705-13 pubmed 出版商
Mungenast A. Diacylglycerol signaling underlies astrocytic ATP release. Neural Plast. 2011;2011:537659 pubmed 出版商
Rodríguez Zayas A, Torrado A, Rosas O, Santiago J, Figueroa J, Miranda J. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. J Mol Neurosci. 2012;46:167-76 pubmed 出版商
Kouzaki H, Iijima K, Kobayashi T, O Grady S, Kita H. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol. 2011;186:4375-87 pubmed 出版商
Thrane A, Rappold P, Fujita T, Torres A, Bekar L, Takano T, et al. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011;108:846-51 pubmed 出版商
Gomez Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, et al. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol. 2010;8:e1000352 pubmed 出版商
Takata N, Hirase H. Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS ONE. 2008;3:e2525 pubmed 出版商
Kennedy C, Tasker P, Gallacher G, Westfall T. Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci. 2007;27:845-51 pubmed
Zhong Y, Dunn P, Burnstock G. Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties. Br J Pharmacol. 2001;132:221-33 pubmed
Liu M, Dunn P, King B, Burnstock G. Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology. Br J Pharmacol. 1999;128:61-8 pubmed
Gao J, Zhao J, Rayner S, Van Helden D. Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2. Br J Pharmacol. 1999;127:1597-602 pubmed
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
0625
SKU号 :
0625/10
产品名称 :
PPADS tetrasodium salt
描述 :
Non-selective P2 antagonist
靶标 :
P2X Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
观察到的分子量 :
599.3
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 u M), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. PPADS tetrasodium salt delays onset of calcium responses to mild hypoosmotic stress in cortical slices. PPADS tetrasodium salt blocks P2X7 and reduces clinical and histological graft-versus-host disease development in a humanised mouse model. . 2 5 -isomer also available.
extended description :
Non-selective P2 antagonist
化学品名文本 :
Pyridoxalphosphate-6-azophenyl-2 ,4 -disulfonic acid tetrasodium salt
配方 :
C 14 H 10 N 3 Na 4 O 12 PS 2
配方文本 :
C14H10N3Na4O12PS2
cas num :
192575-19-2
美元 :
97美元
产品细节 :
Non-selective P2 antagonist
储存 :
Desiccate at -20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国