出版应用/物种/样本/稀释 | 参考文献 |
---|
- 免疫组化基因敲除验证; 小鼠; 1:200; 图 1d
- 免疫印迹基因敲除验证; 小鼠; 图 1e
| Xu J, Wen J, Fu L, Liao L, Zou Y, Zhang J, et al. Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice. J Neuroinflammation. 2021;18:234 pubmed 出版商
|
| Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed 出版商
|
| Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed 出版商
|
| Rivas S, SILVA P, Reyes M, Sepulveda H, Solano L, Acuña J, et al. The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells. Sci Rep. 2020;10:22302 pubmed 出版商
|
- 免疫组化-冰冻切片; 小鼠; 图 1di
- 免疫细胞化学; 小鼠; 1:500; 图 6b
| Moon H, Hippenmeyer S, Luo L, Wynshaw Boris A. LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility. elife. 2020;9: pubmed 出版商
|
| Rangel L, Bernabé Rubio M, Fernández Barrera J, Casares Arias J, Millan J, Alonso M, et al. Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity. Sci Rep. 2019;9:1116 pubmed 出版商
|
| Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed 出版商
|
| Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed 出版商
|
| Bobo Jiménez V, Delgado Esteban M, Angibaud J, Sánchez Morán I, de la Fuente A, Yajeya J, et al. APC/CCdh1-Rock2 pathway controls dendritic integrity and memory. Proc Natl Acad Sci U S A. 2017;114:4513-4518 pubmed 出版商
|
| Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed 出版商
|
| Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink R, Fielden M, et al. RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo. Proc Natl Acad Sci U S A. 2017;114:E1413-E1421 pubmed 出版商
|
| Lovric S, Gonçalves S, Gee H, Oskouian B, Srinivas H, Choi W, et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017;127:912-928 pubmed 出版商
|
| Chen Z, Givens C, Reader J, Tzima E. Haemodynamics Regulate Fibronectin Assembly via PECAM. Sci Rep. 2017;7:41223 pubmed 出版商
|
| Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed 出版商
|
- 免疫细胞化学; 人类; 1:100; 图 s3a
- 免疫印迹; 人类; 1:100; 图 s3c
| Priya R, Liang X, Teo J, Duszyc K, Yap A, Gomez G. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Mol Biol Cell. 2017;28:12-20 pubmed 出版商
|
| Rafiq N, Lieu Z, Jiang T, Yu C, Matsudaira P, Jones G, et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol. 2017;216:181-197 pubmed 出版商
|
| Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget. 2017;8:1304-1320 pubmed 出版商
|
- 免疫组化-石蜡切片; marine lamprey; 1:200; 表 1
| Hu J, Zhang G, Rodemer W, Jin L, Shifman M, Selzer M. The role of RhoA in retrograde neuronal death and axon regeneration after spinal cord injury. Neurobiol Dis. 2017;98:25-35 pubmed 出版商
|
| Yoo S, Leng L, Kim B, Du X, Tilstam P, Kim K, et al. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016;113:E7917-E7926 pubmed
|
| Haak A, Appleton K, Lisabeth E, Misek S, Ji Y, Wade S, et al. Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. Mol Cancer Ther. 2017;16:193-204 pubmed 出版商
|
| Mardakheh F, Self A, Marshall C. RHO binding to FAM65A regulates Golgi reorientation during cell migration. J Cell Sci. 2016;129:4466-4479 pubmed
|
| Shapiro L, Parsons R, Koleske A, Gourley S. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. J Neurosci Res. 2017;95:1123-1143 pubmed 出版商
|
| Forrest C, McNair K, Vincenten M, Darlington L, Stone T. Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer. BMC Cancer. 2016;16:772 pubmed
|
| Kishi T, Mayanagi T, Iwabuchi S, Akasaka T, Sobue K. Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity. Oncotarget. 2016;7:72113-72130 pubmed 出版商
|
- 免疫印迹; African green monkey; 1:1000; 图 3f
| McColl B, Garg R, Riou P, Riento K, Ridley A. Rnd3-induced cell rounding requires interaction with Plexin-B2. J Cell Sci. 2016;129:4046-4056 pubmed
|
| Priya R, Wee K, Budnar S, Gomez G, Yap A, Michael M. Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II. Cell Cycle. 2016;15:3033-3041 pubmed
|
| Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed 出版商
|
- 免疫组化; 人类; 图 2a
- 免疫印迹; 人类; 图 3b
| Yuan W, Guo Y, Li X, Deng M, Shen Z, Bo C, et al. MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway. Oncotarget. 2016;7:60230-60244 pubmed 出版商
|
| Lee S, Jo Y, Namgoong S, Kim N. Anillin controls cleavage furrow formation in the course of asymmetric division during mouse oocyte maturation. Mol Reprod Dev. 2016;83:792-801 pubmed 出版商
|
| Hodgson L, Spiering D, Sabouri Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, et al. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nat Chem Biol. 2016;12:802-809 pubmed 出版商
|
| Whiting J, Ogier L, Forbush K, Bucko P, Gopalan J, Seternes O, et al. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 2016;113:E4328-37 pubmed 出版商
|
- 免疫细胞化学; 人类; 1:200; 图 1
- 免疫印迹; 人类; 1:200; 图 3
| Li Y, Hu Y, Che L, Jia J, Chen M. Nucleolar localization of Small G protein RhoA is associated with active RNA synthesis in human carcinoma HEp-2 cells. Oncol Lett. 2016;11:3605-3610 pubmed
|
| Matsumura S, Kojidani T, Kamioka Y, Uchida S, Haraguchi T, Kimura A, et al. Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1. Nat Commun. 2016;7:ncomms11858 pubmed 出版商
|
| Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed 出版商
|
| Chen L, DeWispelaere A, Dastvan F, Osborne W, Blechner C, Windhorst S, et al. Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity. PLoS ONE. 2016;11:e0155726 pubmed 出版商
|
| Marcos Ramiro B, GarcÃa Weber D, Barroso S, Feito J, Ortega M, Cernuda Morollón E, et al. RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. J Cell Biol. 2016;213:385-402 pubmed 出版商
|
| Wynn M, Yates J, Evans C, Van Wassenhove L, Wu Z, Bridges S, et al. RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells. J Biol Chem. 2016;291:13715-29 pubmed 出版商
|
| Bzymek R, Horsthemke M, Isfort K, Mohr S, Tjaden K, Muller Tidow C, et al. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep. 2016;6:25016 pubmed 出版商
|
| Liu S, Zhou F, Shen Y, Zhang Y, Yin H, Zeng Y, et al. Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells. Oncotarget. 2016;7:32876-92 pubmed 出版商
|
| Chen H, Gao Z, He C, Xiang R, van Kuppevelt T, Belting M, et al. GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA. Exp Cell Res. 2016;343:223-236 pubmed 出版商
|
| Muramatsu T, Kozaki K, Imoto S, Yamaguchi R, Tsuda H, Kawano T, et al. The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene. 2016;35:5304-5316 pubmed 出版商
|
| Lasek A, McPherson B, Trueman N, Burkard M. The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation. PLoS ONE. 2016;11:e0150225 pubmed 出版商
|
| Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, et al. Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat Commun. 2016;7:10664 pubmed 出版商
|
| Fujiwara S, Ohashi K, Mashiko T, Kondo H, Mizuno K. Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement. Mol Biol Cell. 2016;27:954-66 pubmed 出版商
|
| Uehara R, Kamasaki T, Hiruma S, Poser I, Yoda K, Yajima J, et al. Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission. Mol Biol Cell. 2016;27:812-27 pubmed 出版商
|
- 免疫沉淀; 人类; 图 4b
- 免疫印迹; 人类; 图 4b
| Cui H, Wang S, Miao J, Fu Z, Feng F, Wu J, et al. CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling. Oncotarget. 2016;7:5613-29 pubmed 出版商
|
| Kim M, Kim M, Park S, Lee C, Lim D. Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016;17:64-78 pubmed 出版商
|
| Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015;35:14327-40 pubmed 出版商
|
- 免疫细胞化学; 人类; 1:100; 图 s3
- 免疫印迹; 人类; 1:100; 图 s1i
| Priya R, Gomez G, Budnar S, Verma S, Cox H, Hamilton N, et al. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol. 2015;17:1282-93 pubmed 出版商
|
| Namachivayam K, Mohankumar K, Arbach D, Jagadeeswaran R, Jain S, Natarajan V, et al. All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2. PLoS ONE. 2015;10:e0134003 pubmed 出版商
|
| Cao X, Kaneko T, Li J, Liu A, Voss C, Li S. A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration. Nat Commun. 2015;6:7721 pubmed 出版商
|
| Kontro H, Cannino G, Rustin P, Dufour E, Kainulainen H. DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells. PLoS ONE. 2015;10:e0131990 pubmed 出版商
|
| Schiffer M, Teng B, Gu C, Shchedrina V, Kasaikina M, Pham V, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21:601-9 pubmed 出版商
|
| Deglincerti A, Liu Y, Colak D, Hengst U, Xu G, Jaffrey S. Coupled local translation and degradation regulate growth cone collapse. Nat Commun. 2015;6:6888 pubmed 出版商
|
| Fukumoto M, Kurisu S, Yamada T, Takenawa T. α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation. PLoS ONE. 2015;10:e0120616 pubmed 出版商
|
| Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
|
- 免疫细胞化学; 人类; 图 2
- 免疫印迹; 人类; 图 s1
| Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed 出版商
|
| Ferru Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, et al. Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. PLoS ONE. 2015;10:e0118943 pubmed 出版商
|
| Zhang Z, Li J, Wang Q, Zhao W, Hong J, Lou S, et al. WNK1 is involved in Nogo66 inhibition of OPC differentiation. Mol Cell Neurosci. 2015;65:135-42 pubmed 出版商
|
| Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed 出版商
|
| Kaihola H, Olivier J, Poromaa I, Akerud H. The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on nerve growth factor signaling in human placenta. PLoS ONE. 2015;10:e0116459 pubmed 出版商
|
| Yuan Y, Rangarajan P, Kan E, Wu Y, Wu C, Ling E. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. J Neuroinflammation. 2015;12:11 pubmed 出版商
|
| Gao K, Tang W, Li Y, Zhang P, Wang D, Yu L, et al. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. J Cell Sci. 2015;128:992-1000 pubmed 出版商
|
| Shen Y, Gao M, Ma Y, Yu H, Cui F, Gregersen H, et al. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration. Colloids Surf B Biointerfaces. 2015;126:188-97 pubmed 出版商
|
- 免疫组化-自由浮动切片; 小鼠
- 免疫细胞化学; 小鼠
| Toyo oka K, Wachi T, Hunt R, Baraban S, Taya S, Ramshaw H, et al. 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014;34:12168-81 pubmed 出版商
|
| Zuo Y, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells. J Cell Biochem. 2015;116:124-32 pubmed 出版商
|
| Bailon E, Ugarte Berzal E, Amigo Jiménez I, Van den Steen P, Opdenakker G, Garcia Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed 出版商
|
| Mamouni K, Cristini A, Guirouilh Barbat J, Monferran S, Lemarie A, Faye J, et al. RhoB promotes ?H2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol. 2014;34:3144-55 pubmed 出版商
|
| Tang J, Ip J, Ye T, Ng Y, Yung W, Wu Z, et al. Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition. J Neurosci. 2014;34:7425-36 pubmed 出版商
|
| Zemljic Harpf A, Godoy J, Platoshyn O, Asfaw E, Busija A, Domenighetti A, et al. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014;127:1104-16 pubmed 出版商
|
| Nam H, Lee I, Jang S, Bae C, Kwak S, Lee J. p90 ribosomal S6 kinase 1 (RSK1) isoenzyme specifically regulates cytokinesis progression. Cell Signal. 2014;26:208-19 pubmed 出版商
|
| Segatto M, Manduca A, Lecis C, Rosso P, Jozwiak A, Swiezewska E, et al. Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats. Neuropsychopharmacology. 2014;39:841-54 pubmed 出版商
|
| Del Galdo S, Vettel C, Heringdorf D, Wieland T. The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. Cell Signal. 2013;25:2478-84 pubmed 出版商
|
| O Brien M, Carbin S, Morrison J, Smith T. Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy. Reprod Biol Endocrinol. 2013;11:79 pubmed 出版商
|
| Thompson W, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, et al. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013;31:2528-37 pubmed 出版商
|
- 免疫细胞化学; 人类; 1:100
- 免疫印迹; 人类; 1:1000
| Kitagawa M, Fung S, Onishi N, Saya H, Lee S. Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis. PLoS ONE. 2013;8:e64826 pubmed 出版商
|
| Stergiou L, Bauer M, Mair W, Bausch Fluck D, Drayman N, Wollscheid B, et al. Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS ONE. 2013;8:e55799 pubmed 出版商
|
| MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed 出版商
|
| Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, et al. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science. 2010;329:1215-8 pubmed 出版商
|
| Conrad S, Schluesener H, Trautmann K, Joannin N, Meyermann R, Schwab J. Prolonged lesional expression of RhoA and RhoB following spinal cord injury. J Comp Neurol. 2005;487:166-75 pubmed
|
| Deroanne C, Hamelryckx D, Ho T, Lambert C, Catroux P, Lapiere C, et al. Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway. J Cell Sci. 2005;118:1173-83 pubmed
|
| Lee S, Lee S. Prostaglandin F2 Alpha Triggers the Disruption of Cell Adhesion with Cytokeratin and Vimentin in Bovine Luteal Theca Cells. Animals (Basel). 2021;11: pubmed 出版商
|
| Chen A, Ulloa Severino L, Panagiotou T, Moraes T, Yuen D, Lavoie B, et al. Inhibition of polar actin assembly by astral microtubules is required for cytokinesis. Nat Commun. 2021;12:2409 pubmed 出版商
|
| Ma Y, Xia Z, Ye C, Lu C, Zhou S, Pan J, et al. AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion. Aging (Albany NY). 2019;11:3969-3992 pubmed 出版商
|
| Zaoui K, Boudhraa Z, Khalifé P, Carmona E, Provencher D, Mes Masson A. Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion. Nat Commun. 2019;10:2666 pubmed 出版商
|
| Adriaans I, Basant A, Ponsioen B, Glotzer M, Lens S. PLK1 plays dual roles in centralspindlin regulation during cytokinesis. J Cell Biol. 2019;218:1250-1264 pubmed 出版商
|
| McNair K, Forrest C, Vincenten M, Darlington L, Stone T. Serine protease modulation of Dependence Receptors and EMT protein expression. Cancer Biol Ther. 2018;:1-19 pubmed 出版商
|
| Niu X, Su L, Qi S, Gao Z, Zhang Q, Zhang S. GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway. Cell Death Dis. 2018;9:971 pubmed 出版商
|
| Frank S, Köllmann C, Luong P, Galli G, Zou L, Bernards A, et al. p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018;217:3183-3201 pubmed 出版商
|
| Yu O, Benitez J, Plouffe S, Ryback D, Klein A, Smith J, et al. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018;37:5492-5507 pubmed 出版商
|
| Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, et al. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018;37:4385-4397 pubmed 出版商
|
| Zhang G, Hu J, Rodemer W, Li S, Selzer M. RhoA activation in axotomy-induced neuronal death. Exp Neurol. 2018;306:76-91 pubmed 出版商
|
| Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, et al. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. J Cell Biol. 2018;217:1431-1451 pubmed 出版商
|
| Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K. The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin Receptor. J Neurosci. 2018;38:2589-2604 pubmed 出版商
|
| Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, et al. TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling. Cell Discov. 2018;4:1 pubmed 出版商
|
| Shi G, Yang W, Jin L, Matter M, Ramos J. RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A. 2018;115:E190-E199 pubmed 出版商
|
| Cho H, Hwang Y, Yoon J, Lee M, Lee H, Daar I. EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1. Oncogene. 2018;37:861-872 pubmed 出版商
|
| Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017;292:17681-17702 pubmed 出版商
|
| Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert Hilger G, et al. The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif. J Biol Chem. 2017;292:17668-17680 pubmed 出版商
|
| Zaritsky A, Tseng Y, Rabadán M, Krishna S, Overholtzer M, Danuser G, et al. Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. J Cell Biol. 2017;216:1543-1556 pubmed 出版商
|
| Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed 出版商
|
| van de Ven R, de Groot J, Park D, van Domselaar R, de Jong D, Szuhai K, et al. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nat Commun. 2016;7:13874 pubmed 出版商
|
| Gaitanos T, Koerner J, Klein R. Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. J Cell Biol. 2016;214:735-52 pubmed 出版商
|
| Bernard C, Vincent C, Testa D, Bertini E, Ribot J, Di Nardo A, et al. A Mouse Model for Conditional Secretion of Specific Single-Chain Antibodies Provides Genetic Evidence for Regulation of Cortical Plasticity by a Non-cell Autonomous Homeoprotein Transcription Factor. PLoS Genet. 2016;12:e1006035 pubmed 出版商
|
| Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu X, Berndt S, et al. Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody. Toxins (Basel). 2016;8:100 pubmed 出版商
|
| Bendris N, Williams K, Reis C, Welf E, Chen P, Lemmers B, et al. SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases. Mol Biol Cell. 2016;: pubmed
|
| Shankar J, Nabi I. Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells. PLoS ONE. 2015;10:e0119954 pubmed 出版商
|
| Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, et al. RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Nat Commun. 2014;5:5458 pubmed 出版商
|
| Gan C, Patel V, Mikelis C, Zain R, Molinolo A, Abraham M, et al. Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis. Oncotarget. 2014;5:9626-40 pubmed
|
| Koch J, Tönges L, Michel U, Bähr M, Lingor P. Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells. Front Cell Neurosci. 2014;8:273 pubmed 出版商
|
| Schou J, Kelstrup C, Hayward D, Olsen J, Nilsson J. Comprehensive identification of SUMO2/3 targets and their dynamics during mitosis. PLoS ONE. 2014;9:e100692 pubmed 出版商
|
| Hou S, Grillo D, Williams C, Wasserstrom J, Szleifer I, Zhao M. Membrane phospholipid redistribution in cancer micro-particles and implications in the recruitment of cationic protein factors. J Extracell Vesicles. 2014;3: pubmed 出版商
|
| Wu M, Chen C, Lin Y, Jheng Y, Ho Y, Yang L, et al. Divergent signaling pathways cooperatively regulate TGF? induction of cysteine-rich protein 2 in vascular smooth muscle cells. Cell Commun Signal. 2014;12:22 pubmed 出版商
|
| Briz V, Baudry M. Estrogen Regulates Protein Synthesis and Actin Polymerization in Hippocampal Neurons through Different Molecular Mechanisms. Front Endocrinol (Lausanne). 2014;5:22 pubmed 出版商
|
| Sun C, Forster C, Nakamura F, Glogauer M. Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis. PLoS ONE. 2013;8:e79009 pubmed 出版商
|
| Lázaro Diéguez F, Cohen D, Fernandez D, Hodgson L, Van IJzendoorn S, Müsch A. Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes. J Cell Biol. 2013;203:251-64 pubmed 出版商
|
| Weidemann A, Breyer J, Rehm M, Eckardt K, Daniel C, Cicha I, et al. HIF-1? activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells. Cell Commun Signal. 2013;11:80 pubmed 出版商
|
| Yamazaki D, Itoh T, Miki H, Takenawa T. srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity. Mol Biol Cell. 2013;24:3393-405 pubmed 出版商
|
| Joshi A, Dimitropoulou C, Thangjam G, Snead C, Feldman S, Barabutis N, et al. Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. Am J Respir Cell Mol Biol. 2014;50:170-9 pubmed 出版商
|
| Xu J, Li Y, Yang X, Chen Y, Chen M. Nuclear translocation of small G protein RhoA via active transportation in gastric cancer cells. Oncol Rep. 2013;30:1878-82 pubmed 出版商
|
| Suryavanshi N, Ridley A. Determining Rho GTPase activity by an affinity-precipitation assay. Methods Mol Biol. 2013;1046:191-202 pubmed 出版商
|
| Sharp K, Yee K, Stiles T, Aguilar R, Steward O. A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury. Exp Neurol. 2013;248:321-37 pubmed 出版商
|
| Sabbatini M, Williams J. Cholecystokinin-mediated RhoGDI phosphorylation via PKC? promotes both RhoA and Rac1 signaling. PLoS ONE. 2013;8:e66029 pubmed 出版商
|
| Scott S, Xiang Y, Mathews T, Cho H, Myers D, Armstrong M, et al. Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. J Biol Chem. 2013;288:20477-87 pubmed 出版商
|
| Jennissen K, Haas B, Mitschke M, Siegel F, Pfeifer A. Analysis of cGMP signaling in adipocytes. Methods Mol Biol. 2013;1020:175-92 pubmed 出版商
|
| Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth J. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the G?(q/11)--p63RhoGEF--RhoA axis. PLoS Pathog. 2013;9:e1003385 pubmed 出版商
|
| Kobori T, Harada S, Nakamoto K, Tokuyama S. Time-dependent changes in the activation of RhoA/ROCK and ERM/p-ERM in the increased expression of intestinal P-glycoprotein by repeated oral treatment with etoposide. J Pharm Sci. 2013;102:1670-82 pubmed 出版商
|
| Ulmer B, Hagenlocher C, Schmalholz S, Kurz S, Schweickert A, Kohl A, et al. Calponin 2 acts as an effector of noncanonical Wnt-mediated cell polarization during neural crest cell migration. Cell Rep. 2013;3:615-21 pubmed 出版商
|
| Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, et al. Corrigendum: Global quantification of mammalian gene expression control. Nature. 2013;495:126-7 pubmed 出版商
|
| Li D, Dammer E, Lucki N, Sewer M. cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells. Mol Biol Cell. 2013;24:848-57 pubmed 出版商
|
| Korkina O, Dong Z, Marullo A, Warshaw G, Symons M, Ruggieri R. The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion. J Biol Chem. 2013;288:5364-73 pubmed 出版商
|
| Kobori T, Harada S, Nakamoto K, Tokuyama S. Activation of ERM-family proteins via RhoA-ROCK signaling increases intestinal P-gp expression and leads to attenuation of oral morphine analgesia. J Pharm Sci. 2013;102:1095-105 pubmed 出版商
|
| Chen Z, Lessey E, Berginski M, Cao L, Li J, Trepat X, et al. Gleevec, an Abl family inhibitor, produces a profound change in cell shape and migration. PLoS ONE. 2013;8:e52233 pubmed 出版商
|
| Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, et al. Essential role of class II phosphatidylinositol-3-kinase-C2? in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. J Biol Chem. 2013;288:2325-39 pubmed 出版商
|
| Waldmeier L, Meyer Schaller N, Diepenbruck M, Christofori G. Py2T murine breast cancer cells, a versatile model of TGF?-induced EMT in vitro and in vivo. PLoS ONE. 2012;7:e48651 pubmed 出版商
|
| Casteel D, Turner S, Schwappacher R, Rangaswami H, Su Yuo J, Zhuang S, et al. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012;287:38367-78 pubmed 出版商
|
| Kobori T, Kobayashi M, Harada S, Nakamoto K, Fujita Hamabe W, Tokuyama S. RhoA affects oral morphine analgesia depending on functional variation in intestinal P-glycoprotein induced by repeated etoposide treatment. Eur J Pharm Sci. 2012;47:934-40 pubmed 出版商
|
| Noguchi F, Inui S, Nakajima T, Itami S. Hic-5 affects proliferation, migration and invasion of B16 murine melanoma cells. Pigment Cell Melanoma Res. 2012;25:773-82 pubmed 出版商
|
| Chang K, Kao S, Wu Y, Tsai M, Tu H, Liu C, et al. Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA. Oral Oncol. 2013;49:27-33 pubmed 出版商
|
| Tao Y, Chen Y, Lan T, Qian H, Wang Y, Jiang L. LPS-induced nuclear translocation of RhoA is dependent on NF-?B in the human lung cancer cell line A549. Oncol Lett. 2012;3:1283-1287 pubmed
|
| López Gómez A, Cano V, Moranta D, Morey P, Garcia del Portillo F, Bengoechea J, et al. Host cell kinases, ?5 and ?1 integrins, and Rac1 signalling on the microtubule cytoskeleton are important for non-typable Haemophilus influenzae invasion of respiratory epithelial cells. Microbiology. 2012;158:2384-98 pubmed 出版商
|
| Huang J, Haberichter S, Sadler J. The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner. Blood. 2012;120:1143-9 pubmed 出版商
|
| Huang P, Wang J, Shen X, Jiao Q, Cheng Y, Xie B, et al. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. Mol Med Rep. 2012;6:662-6 pubmed 出版商
|
| Steele B, Harper M, Smolenski A, Alkazemi N, Poole A, Fitzgerald D, et al. WNT-3a modulates platelet function by regulating small GTPase activity. FEBS Lett. 2012;586:2267-72 pubmed 出版商
|
| Zhu Y, Kang K, Zhang Y, Qi C, Li G, Yin D, et al. PLD1 Negatively Regulates Dendritic Branching. J Neurosci. 2012;32:7960-9 pubmed 出版商
|
| Xin H, Li Y, Buller B, Katakowski M, Zhang Y, Wang X, et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells. 2012;30:1556-64 pubmed 出版商
|
| Ginestier C, Monville F, Wicinski J, Cabaud O, Cervera N, Josselin E, et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem Cells. 2012;30:1327-37 pubmed 出版商
|
| Chen J, Hou J, Zhang J, An Y, Zhang X, Yue L, et al. Atorvastatin synergizes with IFN-? in treating human non-small cell lung carcinomas via potent inhibition of RhoA activity. Eur J Pharmacol. 2012;682:161-70 pubmed 出版商
|
| Cartier Michaud A, Malo M, Charrière Bertrand C, Gadea G, Anguille C, Supiramaniam A, et al. Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling. PLoS ONE. 2012;7:e32204 pubmed 出版商
|
| Sashio T, Kume H, Takeda N, Asano T, Tsuji S, Kondo M, et al. Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium. Allergol Int. 2012;61:283-93 pubmed 出版商
|
| Howe G, Addison C. RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA. Vasc Cell. 2012;4:1 pubmed 出版商
|
| Arsic N, Bendris N, Peter M, Begon Pescia C, Rebouissou C, Gadea G, et al. A novel function for Cyclin A2: control of cell invasion via RhoA signaling. J Cell Biol. 2012;196:147-62 pubmed 出版商
|
| Guilluy C, Dubash A, Garcia Mata R. Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus. Nat Protoc. 2011;6:2050-60 pubmed 出版商
|
| Jung C, Lee W, Hwang J, Seol S, Kim Y, Lee Y, et al. The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells. Inflammation. 2012;35:1041-8 pubmed 出版商
|
| Jeon C, Moon M, Kim J, Kim H, Kim J, Li Y, et al. Control of neurite outgrowth by RhoA inactivation. J Neurochem. 2012;120:684-98 pubmed 出版商
|
| Greciano P, Moyano J, Buschmann M, Tang J, Lu Y, Rudnicki J, et al. Laminin 511 partners with laminin 332 to mediate directional migration of Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 2012;23:121-36 pubmed 出版商
|
| Rousseau M, Gaugler M, Rodallec A, Bonnaud S, Paris F, Corre I. RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration. Biochem Biophys Res Commun. 2011;414:750-5 pubmed 出版商
|
| Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, et al. Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PLoS ONE. 2011;6:e25465 pubmed 出版商
|
| Bakshi K, Kosciuk M, Nagele R, Friedman E, Wang H. Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP. PLoS ONE. 2011;6:e25019 pubmed 出版商
|
| Zheng S, Huang J, Zhou K, Zhang C, Xiang Q, Tan Z, et al. 17?-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin. PLoS ONE. 2011;6:e22439 pubmed 出版商
|
| Uckert S, Waldkirch E, Kauffels W, Kuczyk M, Hedlund P. Rho kinase-related proteins in human vaginal arteries: an immunohistochemical and functional study. J Sex Med. 2011;8:2739-45 pubmed 出版商
|
| Schackmann R, van Amersfoort M, Haarhuis J, Vlug E, Halim V, Roodhart J, et al. Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J Clin Invest. 2011;121:3176-88 pubmed 出版商
|
| Shen Y, Wang G, Huang X, Zhang Q, Wu J, Tang C, et al. Surface wettability of plasma SiOx:H nanocoating-induced endothelial cells' migration and the associated FAK-Rho GTPases signalling pathways. J R Soc Interface. 2012;9:313-27 pubmed 出版商
|
| Kumar B, Chile S, Ray K, Reddy G, Addepalli M, Kumar A, et al. VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway. Angiogenesis. 2011;14:371-80 pubmed 出版商
|
| Nimnual A, Taylor L, Nyako M, Jeng H, Bar Sagi D. Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b. Small Gtpases. 2010;1:89-97 pubmed
|
| Nakaya M, Ohba M, Nishida M, Kurose H. Determining the activation of rho as an index of receptor coupling to G??/?? proteins. Methods Mol Biol. 2011;746:317-27 pubmed 出版商
|
| Vega F, Fruhwirth G, Ng T, Ridley A. RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol. 2011;193:655-65 pubmed 出版商
|
| Zheng S, Huang J, Zhou K, Xiang Q, Zhang Y, Tan Z, et al. Progesterone enhances vascular endothelial cell migration via activation of focal adhesion kinase. J Cell Mol Med. 2012;16:296-305 pubmed 出版商
|
| Srougi M, Burridge K. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. PLoS ONE. 2011;6:e17108 pubmed 出版商
|
| Sabatel C, Malvaux L, Bovy N, Deroanne C, Lambert V, Gonzalez M, et al. MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PLoS ONE. 2011;6:e16979 pubmed 出版商
|
| Sengottuvel V, Leibinger M, Pfreimer M, Andreadaki A, Fischer D. Taxol facilitates axon regeneration in the mature CNS. J Neurosci. 2011;31:2688-99 pubmed 出版商
|
| Leksa V, Loewe R, Binder B, Schiller H, Eckerstorfer P, Forster F, et al. Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Circ Res. 2011;108:676-85 pubmed 出版商
|
| Anthony D, Sin Y, Vadrevu S, Advant N, Day J, Byrne A, et al. ?-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. Mol Cell Biol. 2011;31:1066-75 pubmed 出版商
|
| Ohsawa M, Aasato M, Hayashi S, Kamei J. RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice. Pain. 2011;152:114-22 pubmed 出版商
|
| Arigami T, Uenosono Y, Hirata M, Hagihara T, Yanagita S, Ishigami S, et al. Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis. J Surg Oncol. 2010;102:748-52 pubmed 出版商
|
| Adams H, Chen R, Liu Z, Whitehead I. Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein. Breast Cancer Res. 2010;12:R69 pubmed 出版商
|
| Henneman L, Schneiders M, Turkenburg M, Waterham H. Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency. J Inherit Metab Dis. 2010;33:625-32 pubmed 出版商
|
| Tsuji T, Ohta Y, Kanno Y, Hirose K, Ohashi K, Mizuno K. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Mol Biol Cell. 2010;21:3590-600 pubmed 出版商
|
| Vogel S, Wottawa M, Farhat K, Zieseniss A, Schnelle M, Le Huu S, et al. Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation. J Biol Chem. 2010;285:33756-63 pubmed 出版商
|
| Rolli Derkinderen M, Toumaniantz G, Pacaud P, Loirand G. RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor alpha and stimulation of vascular smooth muscle cell migration. Mol Cell Biol. 2010;30:4786-96 pubmed 出版商
|
| Fonseca A, Freund D, Bornhauser M, Corbeil D. Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network. J Biol Chem. 2010;285:31661-71 pubmed 出版商
|
| Kümper S, Ridley A. p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. PLoS ONE. 2010;5:e11801 pubmed 出版商
|
| Bush J, Wevrick R. Loss of Necdin impairs myosin activation and delays cell polarization. Genesis. 2010;48:540-53 pubmed 出版商
|
| Pan H, Bachelder R. Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells. Exp Cell Res. 2010;316:2825-32 pubmed 出版商
|
| Oviedo P, Sobrino A, Laguna Fernandez A, Novella S, Tarín J, García Pérez M, et al. Estradiol induces endothelial cell migration and proliferation through estrogen receptor-enhanced RhoA/ROCK pathway. Mol Cell Endocrinol. 2011;335:96-103 pubmed 出版商
|
| Leck Y, Choo Y, Tan C, Smith P, Hagen T. Biochemical and cellular effects of inhibiting Nedd8 conjugation. Biochem Biophys Res Commun. 2010;398:588-93 pubmed 出版商
|
| Nethe M, Anthony E, Fernandez Borja M, Dee R, Geerts D, Hensbergen P, et al. Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci. 2010;123:1948-58 pubmed 出版商
|
| He M, Cheng Y, Li W, Liu Q, Liu J, Huang J, et al. Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade. BMC Cancer. 2010;10:170 pubmed 出版商
|
| Marshall A, Barrett O, Cullingford T, Shanmugasundram A, Sugden P, Clerk A. ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes. PLoS ONE. 2010;5:e10027 pubmed 出版商
|
| Sanno H, Shen X, Kuru N, Bormuth I, Bobsin K, Gardner H, et al. Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density. J Neurosci. 2010;30:4221-31 pubmed 出版商
|
| Fu X, Goglia L, Sanchez A, Flamini M, Giretti M, Tosi V, et al. Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. Endocr Relat Cancer. 2010;17:431-43 pubmed 出版商
|
| Aydin M, Downing K, Villegas G, Zhang X, Chua R, Melman A, et al. The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling. BJU Int. 2010;106:562-71 pubmed 出版商
|
| Dill J, Patel A, Yang X, Bachoo R, Powell C, Li S. A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. J Neurosci. 2010;30:963-72 pubmed 出版商
|
| Cordeiro J, Guerra S, Arakawa Y, Dodding M, Esteban M, Way M. F11-mediated inhibition of RhoA signalling enhances the spread of vaccinia virus in vitro and in vivo in an intranasal mouse model of infection. PLoS ONE. 2009;4:e8506 pubmed 出版商
|
| Elbaz J, Reizel Y, Nevo N, Galiani D, Dekel N. Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles. Endocrinology. 2010;151:755-65 pubmed 出版商
|
| Perez Sala D, Boya P, Ramos I, Herrera M, Stamatakis K. The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway. PLoS ONE. 2009;4:e8117 pubmed 出版商
|
| Vasilaki E, Papadimitriou E, Tajadura V, Ridley A, Stournaras C, Kardassis D. Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways. FASEB J. 2010;24:891-905 pubmed 出版商
|
| Estecha A, Sánchez Martín L, Puig Kröger A, Bartolomé R, Teixido J, Samaniego R, et al. Moesin orchestrates cortical polarity of melanoma tumour cells to initiate 3D invasion. J Cell Sci. 2009;122:3492-501 pubmed 出版商
|
| Ford Speelman D, Roche J, Bowman A, Bloch R. The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle. Mol Biol Cell. 2009;20:3905-17 pubmed 出版商
|
| Cinnamon Y, Feine O, Hochegger H, Bershadsky A, Brandeis M. Cellular contractility requires ubiquitin mediated proteolysis. PLoS ONE. 2009;4:e6155 pubmed 出版商
|
| Niggli V, Schlicht D, Affentranger S. Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells. Biochem Biophys Res Commun. 2009;386:688-92 pubmed 出版商
|
| Rossol Allison J, Stemmle L, Swenson Fields K, Kelly P, Fields P, McCall S, et al. Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal. 2009;21:1559-68 pubmed 出版商
|
| Burkard M, Maciejowski J, Rodriguez Bravo V, Repka M, Lowery D, Clauser K, et al. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 2009;7:e1000111 pubmed 出版商
|
| Braun M, Fountoulakis M, Papadopoulou A, Vougas K, Seidel I, Höller T, et al. Down-regulation of microfilamental network-associated proteins in leukocytes of breast cancer patients: potential application to predictive diagnosis. Cancer Genomics Proteomics. 2009;6:31-40 pubmed
|
| Arnsdorf E, Tummala P, Jacobs C. Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS ONE. 2009;4:e5388 pubmed 出版商
|
| Liu Z, Adams H, Whitehead I. The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration. J Biol Chem. 2009;284:15771-80 pubmed 出版商
|
| Sparano J, Moulder S, Kazi A, Coppola D, Negassa A, Vahdat L, et al. Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer. Clin Cancer Res. 2009;15:2942-8 pubmed 出版商
|
| Monypenny J, Zicha D, Higashida C, Oceguera Yanez F, Narumiya S, Watanabe N. Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis. Mol Cell Biol. 2009;29:2730-47 pubmed 出版商
|
| Arnsdorf E, Tummala P, Kwon R, Jacobs C. Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci. 2009;122:546-53 pubmed 出版商
|
| Penna G, Fibbi B, Amuchastegui S, Corsiero E, Laverny G, Silvestrini E, et al. The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways. Prostate. 2009;69:480-93 pubmed 出版商
|
| Mahtab E, Vicente Steijn R, Hahurij N, Jongbloed M, Wisse L, DeRuiter M, et al. Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Dev Dyn. 2009;238:183-93 pubmed 出版商
|
| Papakonstanti E, Zwaenepoel O, Bilancio A, Burns E, Nock G, Houseman B, et al. Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci. 2008;121:4124-33 pubmed 出版商
|
| Canuel M, Bhattacharyya N, Balbis A, Yuan L, Morales C. Sortilin and prosaposin localize to detergent-resistant membrane microdomains. Exp Cell Res. 2009;315:240-7 pubmed 出版商
|
| Jones G, Tep C, Towns W, Mihai G, Tonks I, Kay G, et al. Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production. Neoplasia. 2008;10:1213-21 pubmed
|
| Andersson E, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, et al. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE. 2008;3:e3517 pubmed 出版商
|
| Groysman M, Shoval I, Kalcheim C. A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells. Neural Dev. 2008;3:27 pubmed 出版商
|
| Lee Z, Cheng C, Zhang H, Subler M, Wu J, Mukherjee A, et al. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol Biol Cell. 2008;19:5435-45 pubmed 出版商
|
| Gadea G, Sanz Moreno V, Self A, Godi A, Marshall C. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol. 2008;18:1456-65 pubmed 出版商
|
| Jaffe T, Schwartz B. Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer. 2008;123:2543-56 pubmed 出版商
|
| Fu X, Giretti M, Baldacci C, Garibaldi S, Flamini M, Sanchez A, et al. Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton. PLoS ONE. 2008;3:e2790 pubmed 出版商
|
| Tillement V, Lajoie Mazenc I, Casanova A, Froment C, Penary M, Tovar D, et al. Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilization. Exp Cell Res. 2008;314:2811-21 pubmed 出版商
|
| Graupera M, Guillermet Guibert J, Foukas L, Phng L, Cain R, Salpekar A, et al. Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. 2008;453:662-6 pubmed 出版商
|
| Golembieski W, Thomas S, Schultz C, Yunker C, McClung H, Lemke N, et al. HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion. Glia. 2008;56:1061-75 pubmed 出版商
|
| Goffinet M, Chinestra P, Lajoie Mazenc I, Medale Giamarchi C, Favre G, Faye J. Identification of a GTP-bound Rho specific scFv molecular sensor by phage display selection. BMC Biotechnol. 2008;8:34 pubmed 出版商
|
| Liu C, Erlichman C, McDonald C, Ingle J, Zollman P, Iankov I, et al. Heat shock protein inhibitors increase the efficacy of measles virotherapy. Gene Ther. 2008;15:1024-34 pubmed 出版商
|
| Thill R, Campbell W, Williams C. Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. J Cell Biochem. 2008;104:1760-70 pubmed 出版商
|
| Bauer T, Motosugi N, Miura K, Sabe H, Hiiragi T. Dynamic rearrangement of surface proteins is essential for cytokinesis. Genesis. 2008;46:152-62 pubmed 出版商
|
| Fu X, Flamini M, Sanchez A, Goglia L, Giretti M, Genazzani A, et al. Progestogens regulate endothelial actin cytoskeleton and cell movement via the actin-binding protein moesin. Mol Hum Reprod. 2008;14:225-34 pubmed 出版商
|
| Chang Y, Nalbant P, Birkenfeld J, Chang Z, Bokoch G. GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA. Mol Biol Cell. 2008;19:2147-53 pubmed 出版商
|
| Fujishiro S, Tanimura S, Mure S, Kashimoto Y, Watanabe K, Kohno M. ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. Biochem Biophys Res Commun. 2008;368:162-7 pubmed 出版商
|
| Liedberg F, Anderson H, Chebil G, Gudjonsson S, Hoglund M, Lindgren D, et al. Tissue microarray based analysis of prognostic markers in invasive bladder cancer: much effort to no avail?. Urol Oncol. 2008;26:17-24 pubmed 出版商
|
| Gaggioli C, Hooper S, Hidalgo Carcedo C, Grosse R, Marshall J, Harrington K, et al. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol. 2007;9:1392-400 pubmed
|
| Zhang Z, Schittenhelm J, Meyermann R, Schluesener H. Lesional accumulation of RhoA(+) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis. Neuropathol Appl Neurobiol. 2008;34:231-40 pubmed
|
| Tew G, Lorimer E, Berg T, Zhi H, Li R, Williams C. SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. J Biol Chem. 2008;283:963-76 pubmed
|
| Kanada M, Nagasaki A, Uyeda T. Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells. Mol Biol Cell. 2008;19:8-16 pubmed
|
| Zhang Z, Fauser U, Schluesener H. Dexamethasone suppresses infiltration of RhoA+ cells into early lesions of rat traumatic brain injury. Acta Neuropathol. 2008;115:335-43 pubmed
|
| Turner S, Zhuang S, Zhang T, Boss G, Pilz R. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008;75:405-13 pubmed
|
| Rupp P, Kulesa P. A role for RhoA in the two-phase migratory pattern of post-otic neural crest cells. Dev Biol. 2007;311:159-71 pubmed
|
| Hirano M, Kanaide H, Hirano K. Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells. Biochim Biophys Acta. 2007;1773:1500-10 pubmed
|
| Gil Henn H, Destaing O, Sims N, Aoki K, Alles N, Neff L, et al. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol. 2007;178:1053-64 pubmed
|
| Ohsawa M, Mutoh J, Hisa H. Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord. Pain. 2008;134:285-92 pubmed
|
| Shachaf C, Perez O, Youssef S, Fan A, Elchuri S, Goldstein M, et al. Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood. 2007;110:2674-84 pubmed
|
| Nikolova E, Mitev V, Minner F, Deroanne C, Poumay Y. The inhibition of the expression of the small Rho GTPase Rac1 induces differentiation with no effect on cell proliferation in growing human adult keratinocytes. J Cell Biochem. 2008;103:857-64 pubmed
|
| Kobune M, Chiba H, Kato J, Kato K, Nakamura K, Kawano Y, et al. Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism. Mol Cancer Ther. 2007;6:1774-84 pubmed
|
| Nikolova E, Mitev V, Zhelev N, Deroanne C, Poumay Y. The small Rho GTPase Rac1 controls normal human dermal fibroblasts proliferation with phosphorylation of the oncoprotein c-myc. Biochem Biophys Res Commun. 2007;359:834-9 pubmed
|
| Sjogren A, Andersson K, Liu M, Cutts B, Karlsson C, Wahlstrom A, et al. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 2007;117:1294-304 pubmed
|
| Fu Q, Hue J, Li S. Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition. J Neurosci. 2007;27:4154-64 pubmed
|
| Kuribayashi K, Nakamura K, Tanaka M, Sato T, Kato J, Sasaki K, et al. Essential role of protein kinase C zeta in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP. J Cell Biol. 2007;176:1049-60 pubmed
|
| Zhang Z, Fauser U, Schluesener H. Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis. J Cell Mol Med. 2007;11:111-9 pubmed
|
| Servotte S, Zhang Z, Lambert C, Ho T, Chometon G, Eckes B, et al. Establishment of stable human fibroblast cell lines constitutively expressing active Rho-GTPases. Protoplasma. 2006;229:215-20 pubmed
|
| Ball S, Shuttleworth C, Kielty C. Platelet-derived growth factor receptor-alpha is a key determinant of smooth muscle alpha-actin filaments in bone marrow-derived mesenchymal stem cells. Int J Biochem Cell Biol. 2007;39:379-91 pubmed
|
| Yanagisawa M, Anastasiadis P. p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J Cell Biol. 2006;174:1087-96 pubmed
|
| Khwaja A, Sharpe C, Noor M, Hendry B. The role of geranylgeranylated proteins in human mesangial cell proliferation. Kidney Int. 2006;70:1296-304 pubmed
|
| Delarue F, Adnane J, Joshi B, Blaskovich M, Wang D, Hawker J, et al. Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter. Oncogene. 2007;26:633-40 pubmed
|
| Pestonjamasp K, Forster C, Sun C, Gardiner E, Bohl B, Weiner O, et al. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood. 2006;108:2814-20 pubmed
|
| Schneiders M, Houten S, Turkenburg M, Wanders R, Waterham H. Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. Arthritis Rheum. 2006;54:2306-13 pubmed
|
| Wheeler A, Wells C, Smith S, Vega F, Henderson R, Tybulewicz V, et al. Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci. 2006;119:2749-57 pubmed
|
| Maqueda A, Moyano J, Gutierrez Lopez M, Ovalle S, Rodríguez Frade J, Cabanas C, et al. Activation pathways of alpha4beta1 integrin leading to distinct T-cell cytoskeleton reorganization, Rac1 regulation and Pyk2 phosphorylation. J Cell Physiol. 2006;207:746-56 pubmed
|
| Dunn S, Youssef S, Goldstein M, Prod homme T, Weber M, Zamvil S, et al. Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J Exp Med. 2006;203:401-12 pubmed
|
| Schubert V, Da Silva J, Dotti C. Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner. J Cell Biol. 2006;172:453-67 pubmed
|
| Zhang Z, Lambert C, Servotte S, Chometon G, Eckes B, Krieg T, et al. Effects of constitutively active GTPases on fibroblast behavior. Cell Mol Life Sci. 2006;63:82-91 pubmed
|
| Waschke J, Burger S, Curry F, Drenckhahn D, Adamson R. Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. Histochem Cell Biol. 2006;125:397-406 pubmed
|
| Salsmann A, Schaffner Reckinger E, Kabile F, Plançon S, Kieffer N. A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreading. J Biol Chem. 2005;280:33610-9 pubmed
|
| Szaszi K, Sirokmány G, Di Ciano Oliveira C, Rotstein O, Kapus A. Depolarization induces Rho-Rho kinase-mediated myosin light chain phosphorylation in kidney tubular cells. Am J Physiol Cell Physiol. 2005;289:C673-85 pubmed
|
| Schwab J, Conrad S, Monnier P, Julien S, Mueller B, Schluesener H. Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM). Eur J Neurosci. 2005;21:1569-76 pubmed
|
| Zhong Z, Huo L, Liang C, Chen D, Sun Q. Small GTPase RhoA is required for ooplasmic segregation and spindle rotation, but not for spindle organization and chromosome separation during mouse oocyte maturation, fertilization, and early cleavage. Mol Reprod Dev. 2005;71:256-61 pubmed
|
| Heneweer C, Schmidt M, Denker H, Thie M. Molecular mechanisms in uterine epithelium during trophoblast binding: the role of small GTPase RhoA in human uterine Ishikawa cells. J Exp Clin Assist Reprod. 2005;2:4 pubmed
|
| Oceguera Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, et al. Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol. 2005;168:221-32 pubmed
|
| Phillips H, Murdoch J, Chaudhry B, Copp A, Henderson D. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005;96:292-9 pubmed
|
| Endo Y, Wolf V, Muraiso K, Kamijo K, Soon L, Uren A, et al. Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem. 2005;280:777-86 pubmed
|
| Danen E, Sonneveld P, Brakebusch C, Fassler R, Sonnenberg A. The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol. 2002;159:1071-86 pubmed
|
| Corre I, Gomez M, Vielkind S, Cantrell D. Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo. J Exp Med. 2001;194:903-14 pubmed
|