抗体

Lamp2抗体

200-501-G10

100微克

单克隆

大鼠

未共轭

GL2A7

抗LAMP2(大鼠)单克隆抗体-200-501

Lamp2抗体

Anti-LAMP2 Antibody is recommended for use in IF microscopy and IP. The antibody will label the presumptive lysosomes and late endosomes in cells that have been permeabilized with saponin. Specific conditions for reactivity should be optimized by the end user.

0.02 M钾磷酸盐, 0.15 M氯化钠, pH值7.2

单克隆

GL2A7

1毫克/毫升

by UV absorbance at 280 nm

(None)

100微克

微克

1:500- 1:1000

User Optimized

Expiration date is one (1) year from date of opening.

IgG1

Lamp2

大鼠

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

LAMP2 Antibody was produced in rat by repeated immunizations with purified preparation of mouse liver lysosomal membranes.

干冰

Liquid (sterile filtered)

0.09%(w/v)叠氮化钠

Anti-LAMP2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with LAMP2 from mouse and rabbit based on 100% homology with the immunizing sequence. Cross-reactivity with LAMP2 from other sources has not been determined.

小鼠, 兔

50%(v/v)甘油

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

IgG1

CD107b, Igp110, Igp2, Lamp2C, LampB, MAC3, Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B

小鼠

Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology. They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane. Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome. This stimulation has also been shown to have an associated release of histamine, leukotriene C and prostaglandin D, which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells. They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation. Anti-LAMP2 antibody is ideal for investigators involved in cytokines, growth factors and cancer research, as well as, Chaperones and Organelle Markers research.

其他

No

No

IF显微镜, 免疫沉淀

一抗

未共轭

P17047

NP_001017959.1

LAMP2免疫荧光