产品简要
公司名称 :
Rockland Immunochemicals
产品类型 :
抗体
产品名称 :
CIITA抗体
目录 :
100-401-249
规格 :
100微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 染色质免疫沉淀 , ChIP-Seq
更多信息或购买 :
Rockland Immunochemicals 产品网页
文章摘录数: 3
出版应用/物种/样本/稀释参考文献
  • ChIP-Seq; 人类; 图 4a
  • 染色质免疫沉淀 ; 人类; 图 4c
Su C, Lu F, Soldan S, Lamontagne R, Tang H, Napoletani G, et al. EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes. PLoS Pathog. 2021;17:e1009834 pubmed 出版商
Majumder P, Lee J, Rahmberg A, Kumar G, Mi T, Scharer C, et al. A super enhancer controls expression and chromatin architecture within the MHC class II locus. J Exp Med. 2020;217: pubmed 出版商
Scharer C, Choi N, Barwick B, Majumder P, Lohsen S, Boss J. Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment. Nucleic Acids Res. 2015;43:3128-42 pubmed 出版商
产品信息
目录号 :
100-401-249
名称 :
抗CIITA氨基酸1-333(兔)抗体-100-401
显示名称 :
CIITA抗体
应用注释 :
For immunoblotting a 1:500 dilution is recommended. Researchers should determine optimal titers for other applications.
克隆性 :
多克隆
浓度值 :
90毫克/毫升
浓度定义 :
by Refractometry
共轭 :
(None)
规格 :
100微升
默认单元 :
微升
ELISA稀释浓度 :
1:5, 000 - 1:25, 000
免疫印迹稀释浓度 :
1:500 - 1:3, 000
有效期 :
Expiration date is one (1) year from date of opening.
格式 :
抗血清
基因名称 :
CIITA
宿主动物 :
兔
一般免责声明 :
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
免疫原 :
The immunogen used for this study was a bacterially produced recombinant FLAG-CIITA corresponding to amino acids 1 through 333 of the human protein.
包装类型 :
干冰
物理状态 :
Liquid (sterile filtered)
防腐剂 :
0.01%(w/v)叠氮化钠
纯度和特异性 :
Anti-CIITA antibody was prepared from monospecific antiserum by delipidation and defibrination.
物种活性 :
人类
储存 :
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
同义词 :
rabbit anti-CIITA Antibody, MHC class II transactivator, CIITA, MHC2TA
靶物种 :
人类
背景 :
Anti-CIITA antibody detects CIITA. The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
免疫原类型 :
重组蛋白
低内毒素 :
No
样品尺寸 :
No
靶活性结构域 :
N末端
应用文本 :
酶联免疫吸附测定, 免疫印迹
其他 :
User Optimized
类别 :
一抗
共轭名称 :
未共轭
UniProt数据库 :
P33076
NCBI :
P33076.2
最初图像名称 :
抗CIITA(1-333)抗体-免疫印迹
更多信息或购买 :
Rockland Immunochemicals 产品网页
公司信息
Rockland Immunochemicals
321 Jones Blvd
Pottstown, PA 19464
orders@rockland-inc.com
https://www.rockland.com/
800-656-7625
公司总部: 美国
Rockland Immunochemicals, Inc.位于宾夕法尼亚州的费城西部，为基础研究、应用研究及临床研究提供磷酸化位点特异性抗体及抗体相关研究工具。公司的技术平台是由一批经验丰富的科学家建立，利用In vitro及In vivo方法制备并纯化单抗及多抗，这些抗体应用于免疫印迹、ELISA、免疫组化、荧光检测、高通量筛选及诊断试剂盒生产等。常用一抗主要应用于以下研究：Akt通路、载脂蛋白、细胞凋亡/细胞周期、细胞因子、细胞信号、酶类、胞外基质、转录因子及泛素相关领域。