产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类ADAM10蛋白, CF
目录 :
936-AD-020
规格 :
20微克
价格 :
544美元
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 22
参考文献
Skokowa J, Hernandez Alvarez B, Coles M, Ritter M, Nasri M, Haaf J, et al. A topological refactoring design strategy yields highly stable granulopoietic proteins. Nat Commun. 2022;13:2948 pubmed 出版商
Yang Y, Tapias V, Acosta D, Xu H, Chen H, Bhawal R, et al. Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nat Commun. 2022;13:159 pubmed 出版商
Renfeng Q, Shuxiao C, Peixian G, Kun L, Xuedong F, Hai Y, et al. ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model. Mol Med Rep. 2021;24: pubmed 出版商
Carreca A, Pravata V, Markham M, Bonelli S, Murphy G, Nagase H, et al. TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1. Sci Rep. 2020;10:12067 pubmed 出版商
Bertran A, Khomiak D, Konopka A, Rejmak E, Bulska E, Seco J, et al. Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorg Chem. 2020;94:103365 pubmed 出版商
Ikeda A, Shahid S, Blumberg B, Suzuki M, Bartlett J. ADAM10 is Expressed by Ameloblasts, Cleaves the RELT TNF Receptor Extracellular Domain and Facilitates Enamel Development. Sci Rep. 2019;9:14086 pubmed 出版商
Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, et al. Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. J Clin Invest. 2019;130:2390-2403 pubmed 出版商
Yoneyama T, Gorry M, Sobo Vujanovic A, Lin Y, Vujanovic L, Gaither Davis A, et al. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. J Cancer. 2018;9:2559-2570 pubmed 出版商
Goto K, Arai J, Stephanou A, Kato N. Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10. Oncotarget. 2018;9:18821-18831 pubmed 出版商
Colombo A, Hsia H, Wang M, Kuhn P, Brill M, Canevazzi P, et al. Non-cell-autonomous function of DR6 in Schwann cell proliferation. EMBO J. 2018;37: pubmed 出版商
Conant K, Daniele S, Bozzelli P, Abdi T, Edwards A, Szklarczyk A, et al. Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation. J Neuroinflammation. 2017;14:56 pubmed 出版商
Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, et al. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Sci Rep. 2016;6:35598 pubmed 出版商
Parra L, Hartmann M, Schubach S, Ma J, Herrlich P, Herrlich A. Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility. Sci Rep. 2016;6:37464 pubmed 出版商
Álvarez Fernández S, Barbariga M, Cannizzaro L, Cannistraci C, Hurley L, Zanardi A, et al. Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients. Oncotarget. 2016;7:80059-80076 pubmed 出版商
Kløverpris S, Mikkelsen J, Pedersen J, Jepsen M, Laursen L, Petersen S, et al. Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A. J Biol Chem. 2015;290:21915-24 pubmed 出版商
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia A, et al. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015;6:6175 pubmed 出版商
Lajoie L, Congy Jolivet N, Bolzec A, Gouilleux Gruart V, Sicard E, Sung H, et al. ADAM17-mediated shedding of Fc?RIIIA on human NK cells: identification of the cleavage site and relationship with activation. J Immunol. 2014;192:741-51 pubmed 出版商
McDonald A, Dibble J, Evans E, Millhauser G. A new paradigm for enzymatic control of ?-cleavage and ?-cleavage of the prion protein. J Biol Chem. 2014;289:803-13 pubmed 出版商
Hayes C, Dey D, Palavicini J, Wang H, Patkar K, Minond D, et al. Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine. BMC Med. 2013;11:81 pubmed 出版商
Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, et al. Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res. 2009;69:8050-7 pubmed 出版商
Moss M, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart P, et al. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem. 2007;282:35712-21 pubmed
Hinkle C, Sunnarborg S, Loiselle D, Parker C, Stevenson M, Russell W, et al. Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem. 2004;279:24179-88 pubmed
产品信息
品牌 :
R&D Systems
master code :
936-AD
SKU号 :
936-AD-020
产品名称 :
重组人类ADAM10蛋白, CF
描述 :
The Recombinant Human ADAM10 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human ADAM10 Protein, CF has been validated for the following applications: Enzyme Activity.
靶标 :
ADAM10
类别 :
蛋白和酶
单位尺寸 :
20微克
缓冲液 :
Supplied as a 0.2 µm filtered solution in MES, NaCl, ZnCl2,Glycerol and Brij-35.
共轭标签 :
未共轭
纯度 :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
人类
观察到的分子量 :
60 kDa, reducing conditions
理论上的分子量 :
52 kDa
基因符号 :
ADAM10
功能细节 :
Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 (Catalog # ES010 ). The specific activity is 20 pmol/min/µg, as measured under the described conditions.
内毒素说明 :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O14672
应用 :
酶活性
来源 :
Sf 21 (baculovirus)-derived Recombinant Human ADAM10 Protein, CF
美元 :
544美元
别名 :
a disintegrin and metalloprotease domain 10, a disintegrin and metalloproteinase domain 10, AD10, ADAM 10, ADAM metallopeptidase domain 10, CD156c, CD156c antigen, CDw156, disintegrin and metalloproteinase domain-containing protein 10, EC 3.4.24, HsT18717, kuz, Kuzbanian, Kuzbanian protein homolog, MADM, MADMEC 3.4.24.81, Mammalian disintegrin-metalloprotease
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.