产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗HER2(磷酸化Tyr1248)抗体
目录 :
43079
规格 :
100微升
价格 :
345美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
更多信息或购买 :
产品信息
目录号 :
43079
产品名称 :
抗HER2(磷酸化Tyr1248)抗体
NAME+SKU :
抗HER2(磷酸化Tyr1248)抗体(43079)
产品_TYPE :
抗体
描述 :
抗HER2(磷酸化Tyr1248)兔多克隆抗体
SPECIFICITY SHORT :
HER2(磷酸化Tyr1248)
物种活性 :
人类, 小鼠, 大鼠
靶标名 :
HER2(磷酸化Tyr1248)
靶抗原修饰 :
磷酸化tyr1248
UniProt数据库 :
P04626
LOCATION :
[Isoform 1]: Cell membrane , Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794).
蛋白名 :
Receptor tyrosine-protein kinase erbB-2
基因名称 :
v-erb-b2成红细胞白血病病毒致瘤基因2
克隆性 :
多克隆
形式 :
液体
浓度 :
1.0毫克/毫升
规格1 :
100微升
标价规格1 :
345美元
DISTIRBUTOR价格 :
241.5
SKU号规格1 :
43079
应用 :
免疫印迹, 免疫组化
应用INSTRUCTIONS :
Immunoblotting: use at dilution of 1:500-1:1,000. A band of ~185kDa is detected.
Immunohistochemistry: use at dilution of 1:50-1:100.
Immunofluorescence: use at dilution of 1:100-1:200.
宿主 :
兔
格式 :
纯化
纯化 :
经免疫亲和层析纯化
免疫原 :
Peptide sequence that includes phosphorylation site of tyrosine 1248 (P-E-Y(p)-L-G) derived from human HER2 and conjugated to KLH.
研究领域 :
磷酸化特异性抗体
配方 :
PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
缓冲液抗MICROBIAL :
0.02% 叠氮化钠
缓冲液CRYOPRESERVATIVE :
50% 甘油
靶标背景 :
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years HER2 has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.
FUNCTION :
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {PubMed:10358079, PubMed:15380516, PubMed:21555369}.
稀释INSTRUCTIONS :
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C. Can be stored at 4C for short-term.
特异性 :
This antibody detects endogenous human, mouse, and rat HER2 only when phosphorylated at tyrosine 1248.Accession no.: P04626, NP_001005862.1
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/273.png)
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com800-929-2114 858-675-2405
公司总部: 美国
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