抗体

抗STAT4(磷酸化Tyr693)抗体

43047

100微升

345美元

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

抗STAT4(磷酸化Tyr693)抗体

抗STAT4(磷酸化Tyr693)抗体(43047)

抗体

抗STAT4(磷酸化Tyr693)兔多克隆抗体

STAT4(磷酸化Tyr693)

人类, 小鼠, 大鼠

STAT4(磷酸化Tyr693)

磷酸化tyr693

Q14765

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Signal transducer and activator of transcription 4

STAT4

多克隆

液体

1.0毫克/毫升

100微升

345美元

241.5

43047

免疫印迹, 免疫组化

Immunoblotting: use at dilution of 1:500-1:1,000. A band of~85kDa is detected. Immunohistochemistry: use at dilution of 1:50- 1:100. These are recommended working dilutions. Enduser should determine optimal dilutions for their applications.

兔

纯化

经免疫亲和层析纯化

Peptide sequence that includes phosphorylation site of tyrosine 693 (K-G-Y(p)-V-P) derived from human STAT4 and conjugated to KLH.

磷酸化特异性抗体

PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

磷酸盐缓冲液

pH值7.4

0.02% 叠氮化钠

50% 甘油

Signal transducers and activators of transcription (STATs) are transcription factors that play important roles in signaling pathways induced by many different cytokines and growth factors that regulate cell growth and differentiation, the immune response, antiviral activity, and homeostasis. Their activation and mechanisms of action are examples of direct signaling to the nucleus by extracellular polypeptide ligands without the involvement of second messengers, tyrosine phosphorylation of transcription factors, or transcription factors that make direct contact with membrane-bound receptors and DNA. Since the discovery of STAT 1 and 2, the family has been expanded to seven members.

Carries out a dual signal transduction and activation of transcription. Involved in IL12 signaling.

Dilute in PBS or medium that is identical to that used in the assay system.

This antibody is stable for at least one (1) year at -20C. Can be stored at 4C for short-term use.

This antibody detects endogenous human, mouse, and rat STAT4 only when phosphorylated at tyrosine 693.