抗体

抗孕酮受体抗体

3341

100微克

461美元

单克隆

小鼠

未共轭

4D8

抗孕酮受体抗体

抗孕酮受体抗体(3341)

抗体

抗孕酮受体小鼠单克隆抗体

孕激素受体

人类

孕激素受体

P06401

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane

孕激素受体

PR, Nuclear receptor subfamily 3 group C member 3

PGR

NP_000917

单克隆

液体

Lot Specific

100微克

461美元

322.7

3341

免疫印迹

Immunoblotting: use at 1-5 ug/ml. Positive controls: MCF7 cells or recombinant protein.

小鼠

纯化

Purified by Protein G affinity chromatography.

IgG2a

4D8

6-His fusion protein containing the region encoding aa 1-101 of human progesterone receptor expressed in E. coli.

Cancer Research

PBS, pH值7.4

磷酸盐缓冲液

pH值7.4

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. {PubMed:10757795, PubMed:1587864, PubMed:9407067, PubMed:7969170, PubMed:8180103, PubMed:8264658, PubMed:10757795}.; [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {PubMed:7969170}.; [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Dilute in PBS or medium which is identical to that used in the assay system.

This antibody is stable for 1 month at 4°C or one year at -20°C. Avoid multiple freeze-thaw cycles.

This antibody recognizes human progesterone receptor (PgR), a member of the steroid family of nuclear receptors. PgR is found as a 94 kD protein (Form A) or a 120 kD protein (Form B). Binding of progesterone to its receptor results in a conformational change that allows dimerization and binding of the receptor to progesterone response elements and activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription.