产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
Anti-CD4 Cytoplasmic Tail Antibody
目录 :
18714
规格 :
100微克
价格 :
358美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
8A5
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
18714
产品名称 :
Anti-CD4 Cytoplasmic Tail Antibody
NAME+SKU :
Anti-CD4 Cytoplasmic Tail Antibody (18714)
产品_TYPE :
抗体
描述 :
Anti-CD4 Cytoplasmic Tail Mouse Monoclonal Antibody
SPECIFICITY SHORT :
CD4 Cytoplasmic Tail
物种活性 :
人类
靶标名 :
CD4 Cytoplasmic Tail
UniProt数据库 :
P01730
LOCATION :
细胞膜
蛋白名 :
T细胞表面的糖蛋白CD4
别称 :
T-cell surface antigen T4/Leu-3, CD antigen CD4
基因名称 :
CD4
登录号 :
NP_000607
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
358美元
DISTIRBUTOR价格 :
250.6
SKU号规格1 :
18714
应用 :
酶联免疫吸附测定, IF
应用INSTRUCTIONS :
ELISA: use at 10-20ug/ml. Optimized with 25ug cell lysate (Jurkat, H9, HeLa) on the solid phase.
Immunofluorescence: use at 5-10ug/ml. Optimized with CEM cells adhered to glass slides with poly-L-lysine and fixed in paraformaldehyde.
宿主 :
小鼠
格式 :
纯化
纯化 :
经免疫亲和层析纯化
抗体亚型 :
IgM
克隆编号 :
8A5
免疫原 :
Synthetic peptide corresponding to aa sequence RFLPADQMNVADPQPLASCS at the post 3’-UGA codon region of CD4.
研究领域 :
细胞粘附
配方 :
PBS, pH值7.4
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
靶标背景 :
CD4 is a co-receptor of the T-cell receptor (TCR) and assists the TCR in communicating with antigen-presenting cells. The short cytoplasmic/intracellular tail of CD4 contains a special sequence of amino acids that allow it to recruit and interact with the tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase). When the TCR and CD4 bind to distinct regions of an antigen-presenting MHCII molecule, tyrosine kinase Lck bound to the cytoplasmic tail of CD4 tyrosine-phosphorylates immunoreceptor tyrosine activation motifs (ITAM) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR. Many functions have been assigned to the cytoplasmic tail of CD4 including anti-viral regulation (down/up regulation of CD4), T-cell maturation, activation and differentiation, and Lck signal transmission.
FUNCTION :
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {PubMed:16951326, PubMed:24942581, PubMed:2823150, PubMed:7604010}.; (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607). {PubMed:12089508, PubMed:16331979, PubMed:17346169, PubMed:2214026, PubMed:7909607, PubMed:9641677}.
稀释INSTRUCTIONS :
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C to -70C. Store antibody in appropriate aliquots to avoid multiple freeze-thaw cycles.
特异性 :
This antibody recognizes the post 3’-UGA codon region of human CD4.
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/273.png)
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com800-929-2114 858-675-2405
公司总部: 美国
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