产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗血红素氧化酶抗体
目录 :
13060
规格 :
100微克
价格 :
509美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
GTS-1
反应物种 :
人类, 小鼠, 大鼠
更多信息或购买 :
QED Bioscience 产品网页
图像
图像 1 :
QED Bioscience 13060 图像 1
Immunoblotting: use at 5-10ug/ml. A band of ~33kDa is detected. Detection of rat HO-1 with #13060 at 5ug/ml.
图像 2 :
QED Bioscience 13060 图像 2
Immunohistochemistry: use at 5-10ug/ml on human frozen or paraffin-embedded tissue. Antigen retrieval with 0.4ug/ml Proteinase K.
产品信息
目录号 :
13060
产品名称 :
抗血红素氧化酶抗体
NAME+SKU :
抗血红素氧化酶抗体(13060)
产品_TYPE :
抗体
描述 :
抗血红素氧化酶小鼠单克隆抗体
SPECIFICITY SHORT :
血红素氧化酶
物种活性 :
人类, 小鼠, 大鼠
靶标名 :
血红素氧化酶
UniProt数据库 :
P09601
LOCATION :
Microsome , Endoplasmic reticulum membrane , Peripheral membrane protein , Cytoplasmic side
蛋白名 :
血红素氧化酶
别称 :
HO-1, EC 1.14.14.18
基因名称 :
HMOX1
登录号 :
NP_002124
克隆性 :
单克隆
形式 :
冻干
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
509美元
DISTIRBUTOR价格 :
356.3
SKU号规格1 :
13060
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 中和反应
应用INSTRUCTIONS :
Immunoblotting: use at 5-10ug/ml. A band of ~33kDa is detected. Immunohistochemistry: use at 5-10ug/ml on human frozen or paraffin-embedded tissue. Antigen retrieval with 0.4ug/ml Proteinase K. These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
宿主 :
小鼠
格式 :
纯化
纯化 :
经免疫亲和层析纯化
抗体亚型 :
IgG1
克隆编号 :
GTS-1
免疫原 :
Microsomal fraction of transformed mouse T-cell transfected with rat heme oxygenase- 1 (WR19LrHO-1).
研究领域 :
酶
配方 :
PBS, pH值7.4, 1% BSA., 冻干
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
Heme-oxygenase is an enzyme that catalyzes heme catabolism to yield biliverdin, iron, and carbon monoxide (CO). There are three isoforms of heme-oxygenase: HO-1, HO-2, and HO-3. HO-1 and HO-2 have been identified as the two major isoforms in mammals. HO-1, also known as heat shock protein 32 (Hsp32) is induced by most oxidative stress inducers, cytokines, inflammatory agents, and heat shock. HO-1 deficiency appears to cause reduced stress defense, a pro-inflammatory tendency, susceptibility to atherosclerotic lesion formation, endothelial cell injury, and growth retardation. Therefore, up-regulation of HO-1 is one of the major defense mechanisms against oxidative stress.
FUNCTION :
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
STORAGE空调 :
This antibody is stable at 2 – 8C for one (1) year from date of receipt.
特异性 :
This antibody recognizes human, rat, and mouse HO-1. It does not recognize rabbit HO-1 and does not cross-react with HO-2.
图像Name_1 :
qed-bioscience-anti-heme-oxygenase-1-antibody-13060-1.jpg
应用1 :
免疫印迹
图像Name_2 :
qed-bioscience-anti-heme-oxygenase-1-antibody-13060-2.jpg
应用2 :
免疫组化
更多信息或购买 :
QED Bioscience 产品网页
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国