抗体

小鼠单克隆抗体RAN

30993

0.1毫克

341.00美元

单克隆

小鼠

nonconjugated

8D1A6

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪

小鼠单克隆抗体RAN

Human; Mouse; Monkey; Rat;

8D1A6;

小鼠IgG1

0.1毫克

4℃;-20℃为长期储存

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.;

纯化重组片段对应于人RAN(AA: 1-216)在大肠杆菌中表达

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000;WB: 1/500 - 1/2000;IHC: 1/200 - 1/1000;ICC: 1/200 - 1/1000;FCM: 1/200 - 1/400

1.Int J Clin Oncol. 2013 Oct;18(5):856-63. ; 2.Clin Cancer Res. 2012 Jan 15;18(2):380-91.;

341.00美元

单克隆抗体

24.4kDa

TC4;Gsp1;ARA24