产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
Rad50抗体(13B3)
目录 :
NB100-147.1毫升
规格 :
0.1毫升
价格 :
449美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
13B3
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 77
参考文献 |
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Chen H, Ma Z, VanderWaal R, Feng Z, Gonzalez Suarez I, Wang S, et al. The mTOR inhibitor rapamycin suppresses DNA double-strand break repair. Radiat Res. 2011;175:214-24 pubmed
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Schwartz R, Palacios J, Cassell G, Adam S, Giacca M, Weitzman M. The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol. 2007;81:12936-45 pubmed
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Gorodetsky E, Calkins S, Ahn J, Brooks P. ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. DNA Repair (Amst). 2007;6:1698-707 pubmed
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Zhong Z, Jiang W, Cesare A, Neumann A, Wadhwa R, Reddel R. Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem. 2007;282:29314-22 pubmed
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Bentle M, Reinicke K, Dong Y, Bey E, Boothman D. Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone. Cancer Res. 2007;67:6936-45 pubmed
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Cho Y, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007;282:20395-406 pubmed
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Bae N, Baumann P. A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell. 2007;26:323-34 pubmed
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Lin X, Liu C, Gao Q, Zhang X, Wu G, Lee W. RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Mol Cell Biol. 2007;27:4905-16 pubmed
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You K, Li L, Kim N, Kang H, Koh K, Chwae Y, et al. Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLoS Biol. 2007;5:e109 pubmed
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Dote H, Burgan W, Camphausen K, Tofilon P. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006;66:9211-20 pubmed
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Takemura H, Rao V, Sordet O, Furuta T, Miao Z, Meng L, et al. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem. 2006;281:30814-23 pubmed
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Kong L, Meloni A, Nevins J. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Mol Cell. 2006;22:63-71 pubmed
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Myers J, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem. 2006;281:9346-50 pubmed
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Tommiska J, Seal S, Renwick A, Barfoot R, Baskcomb L, Jayatilake H, et al. Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer. 2006;118:2911-6 pubmed
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Al Rashid S, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, et al. Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res. 2005;65:10810-21 pubmed
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Mongiat Artus P, Miquel C, van der Aa M, Buhard O, Hamelin R, Soliman H, et al. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Oncogene. 2006;25:2113-8 pubmed
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Liu Y, Shevchenko A, Shevchenko A, Berk A. Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex. J Virol. 2005;79:14004-16 pubmed
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Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
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Koh K, Kang H, Li L, Kim N, You K, Yang E, et al. Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. Lab Invest. 2005;85:1130-8 pubmed
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van Veelen L, Cervelli T, van de Rakt M, Theil A, Essers J, Kanaar R. Analysis of ionizing radiation-induced foci of DNA damage repair proteins. Mutat Res. 2005;574:22-33 pubmed
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Lilley C, Carson C, Muotri A, Gage F, Weitzman M. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc Natl Acad Sci U S A. 2005;102:5844-9 pubmed
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Fasching C, Bower K, Reddel R. Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies. Cancer Res. 2005;65:2722-9 pubmed
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Angele S, Jones C, Reis Filho J, Fulford L, Treilleux I, Lakhani S, et al. Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast. J Clin Pathol. 2004;57:1179-84 pubmed
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Wu X, Avni D, Chiba T, Yan F, Zhao Q, Lin Y, et al. SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Genes Dev. 2004;18:1305-16 pubmed
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O Connor M, Safari A, Liu D, Qin J, Songyang Z. The human Rap1 protein complex and modulation of telomere length. J Biol Chem. 2004;279:28585-91 pubmed
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Wilkinson D, Weller S. Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respon. J Virol. 2004;78:4783-96 pubmed
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Dork T, Bendix Waltes R, Wegner R, Stumm M. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A. 2004;126A:272-7 pubmed
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Giannini G, Rinaldi C, Ristori E, Ambrosini M, Cerignoli F, Viel A, et al. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene. 2004;23:2640-7 pubmed
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Carson C, Schwartz R, Stracker T, Lilley C, Lee D, Weitzman M. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 2003;22:6610-20 pubmed
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Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003;22:5612-21 pubmed
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Xu X, Stern D. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003;17:1842-8 pubmed
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Angele S, Treilleux I, Bremond A, Taniere P, Hall J. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Histopathology. 2003;43:347-53 pubmed
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Evans J, Hearing P. Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation. J Virol. 2003;77:5295-304 pubmed
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Stewart G, Wang B, Bignell C, Taylor A, Elledge S. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003;421:961-6 pubmed
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Anderson L, Perkins N. Regulation of RelA (p65) function by the large subunit of replication factor C. Mol Cell Biol. 2003;23:721-32 pubmed
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Hassane D, Lee R, Pickett C. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect Immun. 2003;71:541-5 pubmed
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Richie C, Peterson C, Lu T, Hittelman W, Carpenter P, Legerski R. hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. Mol Cell Biol. 2002;22:8635-47 pubmed
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Pichierri P, Averbeck D, Rosselli F. DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Hum Mol Genet. 2002;11:2531-46 pubmed
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Kim J, Krasieva T, LaMorte V, Taylor A, Yokomori K. Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem. 2002;277:45149-53 pubmed
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Stracker T, Carson C, Weitzman M. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 2002;418:348-52 pubmed
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Franchitto A, Pichierri P. Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. J Cell Biol. 2002;157:19-30 pubmed
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Carbone R, Pearson M, Minucci S, Pelicci P. PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage. Oncogene. 2002;21:1633-40 pubmed
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Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol Immunol. 2000;37:915-29 pubmed
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Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, et al. The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity. J Biol Chem. 2001;276:12-5 pubmed
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Paull T, Rogakou E, Yamazaki V, Kirchgessner C, Gellert M, Bonner W. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000;10:886-95 pubmed
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Wang Y, Cortez D, Yazdi P, Neff N, Elledge S, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000;14:927-39 pubmed
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图像
图像 1 :
![Novus Biologicals NB100-147-0.1ml 图像 1](http://www.labome.com/product/Novus-Biologicals/6420592_0.jpg)
Western Blot: Rad50 Antibody (13B3) [NB100-147] - HeLa whole cell and nuclear extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with Rad50 antibody [N1N2], N-term diluted at 1:500.
产品信息
品牌 :
Novus
MasterCode :
NB100-147
SKU号 :
NB100-147.1毫升
产品名称 :
Rad50抗体(13B3)
描述 :
The Rad50 Antibody (13B3) from NB100-147-0.1ml is a nb100-147 antibody to . This antibody reacts with breast cancer, dna repair, homologous recombination.
靶标 :
Rad50
类别 :
一抗
单位尺寸 :
0.1毫升
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
13B3
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Amino acids 1-425 of Rad50 expressed in E. coli.
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
Human, Mouse, Rat, Monkey
特异性 :
This is specific for Rad50
理论上的分子量 :
153 kDa
基因符号 :
RAD50
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Western-Blot-NB100-147-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Western-Blot-NB100-147-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunocytochemistry-Immunofluorescence-NB100-147-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunocytochemistry-Immunofluorescence-NB100-147-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Western-Blot-NB100-147-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Western-Blot-NB100-147-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Immunohistochemistry-Paraffin-NB100-147-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Western-Blot-NB100-147-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Rad50-Antibody-(13B3)-Western-Blot-NB100-147-img0013.jpg
应用 :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, In vitro assay, Knockdown Validated
美元 :
449美元
别名 :
DNA repair protein RAD50, EC 3.6, EC 3.6.1.15, EC 3.6.3, EC 3.6.3.27, hRAD50, NBSLD, RAD50 (S. cerevisiae) homolog, RAD50 homolog (S. cerevisiae), RAD502, RAD50-2
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/9.jpg)
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。