蛋白

Recombinant Mouse Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a)

MBS963288

0.5毫克(大肠杆菌)

1455美元

重组蛋白

Recombinant Mouse Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a)

Protein phosphatase 1 regulatory subunit 15A (Ppp1r15a)

Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116

protein phosphatase 1 regulatory subunit 15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; growth arrest and DNA damage-inducible protein GADD34; myeloid differentiation primary response protein MyD116; protein phosphatase 1, regulatory (inhibitor) subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116

Ppp1r15a

Ppp1r15a;Gadd34;Myd116

Ppp1r15a;Ppp1r15a;Gadd34;Myd116;9630030H21;Gadd34;Myd116

PR15A_MOUSE

E Coli or Yeast or Baculovirus or Mammalian Cell

1-657

657

MAPSPRPQHV LHWRDAHNFY LLSPLMGLLS RAWSRLRGPE VPEAWLAKTV TGADQIEAAA LLTPTPVSGN LLPHGETEES GSPEQSQAAQ RLCLVEAESS PPETWGLSNV DEYNAKPGQD DLREKEMERT AGKATLQPAG LQGADKRLGE VVAREEGVAE PAYPTSQLEG GPAENEEDGE TVKTYQASAA SIAPGYKPST PVPFLGEAEH QATEEKGTEN KADPSNSPSS GSHSRAWEYY SREKPKQEGE AKVEAHRAGQ GHPCRNAEAE EGGPETTFVC TGNAFLKAWV YRPGEDTEEE DNSDSDSAEE DTAQTGATPH TSAFLKAWVY RPGEDTEEED SDSDSAEEDT AQTGATPHTS AFLKAWVYRP GEDTEEENSD LDSAEEDTAQ TGATPHTSAF LKAWVYRPGE DTEEENSDLD SAEEDTAQTG ATPHTSPFLK AWVYRPGEDT EDDTEEEEDS ENVAPGDSET ADSSQSPCLQ PQRCLPGEKT KGRGEEPPLF QVAFYLPGEK PESPWAAPKL PLRLQRRLRL FKAPTRDQDP EIPLKARKVH FAEKVTVHFL AVWAGPAQAA RRGPWEQFAR DRSRFARRIA QAEEKLGPYL TPDSRARAWA RLRNPSLPQS EPRSSSEATP LTQDVTTPSP LPSETPSPSL YLGGRRG

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Mus musculus (Mouse)

6678978

NP_032680.1

NM_008654.2

P17564

63,474 Da

Downregulation Of TGF-beta Receptor Signaling Pathway (819823); Protein Processing In Endoplasmic Reticulum Pathway (167331); Protein Processing In Endoplasmic Reticulum Pathway (167190); Signal Transduction Pathway (819739); Signaling By TGF-beta Receptor Complex Pathway (819821); TGF-beta Receptor Signaling Activates SMADs Pathway (819822)

GADD34: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on Ser-15 . Belongs to the PPP1R15 family. Protein type: DNA repair, damage; Cell cycle regulation; Apoptosis; Translation initiation. Cellular Component: Golgi apparatus; mitochondrial outer membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; protein phosphatase type 1 complex. Molecular Function: protein phosphatase regulator activity; protein kinase binding; protein phosphatase binding; protein phosphatase 1 binding. Biological Process: regulation of translation; positive regulation of phosphoprotein phosphatase activity; negative regulation of protein amino acid dephosphorylation; unfolded protein response; apoptosis; negative regulation of phosphoprotein phosphatase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase I promoter

0.5毫克(大肠杆菌)

1455美元

0.05毫克(杆状病毒)

1455

0.5毫克(酵母)

1685

0.05 mg (Mammalian-Cell)

1685

1毫克(大肠杆菌)

2480