抗体

ABCA1抗体

MBS9401490

0.05毫升

200美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

抗体

ABCA1抗体

[ABCA1]

[TGD;ABC1;CERP;ABC-1]

[ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein]

[ABCA1]

[ABCA1; ABCA1; TGD; ABC1; CERP; ABC-1; HDLDT1; ABC1; CERP; ABC-1; ATP-binding cassette 1]

ABCA1_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

2261

抗体检测内生水平总数ABCA1蛋白

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0毫克/毫升

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

免疫印迹(免疫印迹)

Western blotting: 1:500~1:1000

免疫印迹(免疫印迹)

Immunogen Type: Peptide-KLH. Immunogen Description: Peptide sequence around aa.2253~2257(D-E-K-V-K) derived from Human ABCA1.

Target Name: ABCA1

总数蛋白Ab

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.

21536376

NP_005493.2

NM_005502.3

O95477

254 kd

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Folate Metabolism Pathway (198833); HDL-mediated Lipid Transport Pathway (1270007); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Lipoprotein Metabolism Pathway (1270005); Metabolism Pathway (1269956)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies. Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Vesicle; Membrane protein, integral. Chromosomal Location of Human Ortholog: 9q31.1. Cellular Component: Golgi apparatus; endocytic vesicle; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft. Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; cholesterol binding; apolipoprotein binding; ATPase binding; apolipoprotein A-I binding; small GTPase binding; protein binding; phospholipid transporter activity; syntaxin binding; cholesterol transporter activity; phospholipid binding; anion transmembrane transporter activity; ATP binding; receptor binding. Biological Process: response to drug; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; lipoprotein metabolic process; intracellular cholesterol transport; cholesterol efflux; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; platelet dense granule organization and biogenesis; phospholipid efflux; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; response to nutrient; phospholipid homeostasis; peptide secretion. Disease: Tangier Disease; Hypoalphalipoproteinemia, Primary; Hypercholesterolemia, Familial

0.05毫升

200美元

0.1毫升

255