MCTS1抗体 | MyBioSource MBS9401306 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

MCTS1抗体

MBS9401306

规格 :

0.1毫升

价格 :

255美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类

应用 :

免疫印迹, 免疫组化

更多信息或购买 :

MyBioSource 产品网页

图像

图像 1 :

Gel: 10%SDS-PAGE Lysates (from left to right): Jurkat and K562 cell, PC3 and A549 cell Amount of lysate: 40ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes

图像 2 :

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/30.

产品信息

目录号 :

MBS9401306

产品类型 :

抗体

产品全称 :

MCTS1抗体

产品简称 :

[MCTS1]

产品名称同义词 :

[MCT1;MCT-1]

其他名称 :

[malignant T-cell-amplified sequence 1 isoform 2; Malignant T-cell-amplified sequence 1; malignant T-cell-amplified sequence 1; malignant T cell amplified sequence 1; Multiple copies T-cell malignancies]

产品基因名称 :

[MCTS1]

其他基因名称 :

[MCTS1;MCTS1;MCT1;MCT-1;MCT1;MCT-1]

UniProt数据库进入名 :

MCTS1_HUMAN

克隆性 :

多克隆

宿主 :

兔

反应物种 :

人类

序列长度 :

182

特异性 :

抗体检测内生水平总数MCTS1蛋白

纯度 :

抗原亲和纯化

形式 :

兔IgG在pH7.3 PBS, 0.05% NaN3, 50% 甘油

浓度 :

1.3毫克/毫升

储存稳定性 :

存放在-20°C

检测过的应用 :

免疫印迹(免疫印迹), 免疫组化(免疫组化)

应用笔记 :

Western blotting: 1:200-1:1000. Immunohistochemistry: 1:50-1:200

image1头 :

试验数据

image2头 :

免疫组化(免疫组化)

其它信息1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Full length fusion protein. SDS-PAGE MW: 21 kDa

其他信息2 :

Target Name: MCTS1

产品种类 :

总数蛋白Ab

产品描述 :

MCTS1 (malignant T cell amplified sequence 1), also known as MCT1, is a 181 amino acid protein that is ubiquitously expressed and localizes to the cytoplasm of cells. MCTS1 may play a role in cell cycle regulation by decreasing cell doubling time and by shortening the duration of G1 transit time and G1/S transition. The protein level of Cdk4 and Cdk6 kinases activity and cyclin D1 is enhanced by expression of MCTS1. As a translation enhancer, MCTS1 recruits DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile. MCTS1 promotes lymphoid tumor development and contributes to the pathogenesis and progression of breast cancer. MCTS1 positively regulates phosphorylation of ERK1 and ERK2.

NCBI GI登录号 :

212276121

NCBI登录号 :

NP_001131026.1

NCBI基因登录号 :

NM_001137554.1

UniProt数据库登录号 :

Q9ULC4

UniProt数据库总结 :

MCTS1: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5 -terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Belongs to the MCTS1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor. Chromosomal Location of Human Ortholog: Xq24. Cellular Component: cytoplasm; plasma membrane. Molecular Function: translation initiation factor activity. Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of growth; positive regulation of cell proliferation; ribosome disassembly; cell cycle; response to DNA damage stimulus; formation of translation preinitiation complex

尺寸1 :

0.1毫升

价格1 :

255美元

更多信息或购买 :

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公司信息