抗体

CD155多克隆抗体

MBS9401179

0.05毫升

200美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

CD155多克隆抗体

[CD155]

[PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155]

[poliovirus receptor isoform beta; Poliovirus receptor; poliovirus receptor; poliovirus receptor; Nectin-like protein 5; NECL-5; CD_antigen: CD155]

[CD155]

[PVR; PVR; PVS; HVED; CD155; NECL5; TAGE4; Necl-5; PVS; NECL-5]

PVR_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

372

CD155多克隆抗体检测内生水平CD155蛋白

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

液体PBS含50% 甘油, 0.5% BSA和0.02% 叠氮化钠

1毫克/毫升

Store at -20°C/1 year

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

Western Blot: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the Internal region of human CD155. SDS-PAGE MW: 45kd

Target Name: CD155

总数蛋白Ab

209413728

NP_001129240.1

NM_001135768.2

P15151

Adaptive Immune System Pathway (1269171); Adherens Junctions Interactions Pathway (1270234); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Nectin Adhesion Pathway (138054)

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

PVR: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Immunoglobulin superfamily; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: extracellular space; cell surface; focal adhesion; cytoplasm; plasma membrane; integral to membrane. Molecular Function: viral receptor activity; protein binding; receptor activity; cell adhesion molecule binding. Biological Process: intercellular junction assembly and maintenance; entry of virus into host cell; cell-cell adhesion; regulation of immune response; cell migration; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; response to virus; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity

0.05毫升

200美元

0.1毫升

255