抗体

HPRT1抗体

MBS9401129

0.1毫升

255美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

抗体

HPRT1抗体

[HPRT1]

[HPRT;次黄嘌呤鸟嘌呤磷酸核糖基转移酶]

[hypoxanthine-guanine phosphoribosyltransferase; Hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine phosphoribosyltransferase 1]

[HPRT1]

[HPRT1;HPRT1;HPRT;次黄嘌呤鸟嘌呤磷酸核糖基转移酶;HPRT;次黄嘌呤鸟嘌呤磷酸核糖基转移酶;HGPRTase]

HPRT_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

218

抗体检测内生水平总数HPRT1蛋白

Antibodies were purified by affinity purification using immunogen.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0毫克/毫升

Store at -20 degree C

免疫印迹(免疫印迹), 免疫组化(免疫组化)

Western blotting: 1:500 - 1:2000. Immunohistochemistry: 1:50 - 1:200

免疫印迹(免疫印迹)

Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human HPRT1.

Target Name: HPRT1

总数蛋白Ab

The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.

4504483

NP_000185.1

NM_000194.2

P00492

24KD

Drug Metabolism - Other Enzymes Pathway (83033); Drug Metabolism - Other Enzymes Pathway (428); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Nucleotides Pathway (1270133); Nucleotide Metabolism Pathway (198876); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (1270134); Purine Metabolism Pathway (307); Purine Salvage Pathway (1270136)

The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]

HPRT1: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS). LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT); also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Protein type: EC 2.4.2.8; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Cell development/differentiation; Nucleotide Metabolism - purine. Chromosomal Location of Human Ortholog: Xq26.1. Cellular Component: cytoplasm; cytosol. Molecular Function: protein binding; protein homodimerization activity; nucleotide binding; magnesium ion binding; hypoxanthine phosphoribosyltransferase activity. Biological Process: grooming behavior; hypoxanthine metabolic process; lymphocyte proliferation; IMP salvage; striatum development; nucleobase, nucleoside and nucleotide metabolic process; GMP salvage; cytolysis; dendrite morphogenesis; response to amphetamine; adenine salvage; locomotory behavior; purine nucleotide biosynthetic process; dopamine metabolic process; purine base metabolic process; purine salvage; protein homotetramerization; cerebral cortex neuron differentiation; GMP catabolic process; positive regulation of dopamine metabolic process; IMP metabolic process; hypoxanthine salvage; purine ribonucleoside salvage; central nervous system neuron development; guanine salvage. Disease: Kelley-seegmiller Syndrome; Lesch-nyhan Syndrome

0.1毫升

255美元