产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
BDNF抗体(C末端)
目录 :
MBS9211799
规格 :
0.08毫升
价格 :
165美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
![MyBioSource MBS9211799 图像 1](http://www.labome.com/product/MyBioSource/6062143_0.jpg)
All lanes : Anti-BDNF Antibody (C-term) at 1:1000 dilution Lane 1: human cerebellum lysate Lane 2: U-87 MG whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST
图像 2 :
![MyBioSource MBS9211799 图像 2](http://www.labome.com/product/MyBioSource/6062143_1.jpg)
Formalin-fixed and paraffin-embedded human brain reacted with BDNF Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
图像 3 :
![MyBioSource MBS9211799 图像 3](http://www.labome.com/product/MyBioSource/6062143_2.jpg)
Confocal immunofluorescent analysis of BDNF Antibody (C-term) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
产品信息
目录号 :
MBS9211799
产品类型 :
抗体
产品全称 :
BDNF抗体(C末端)
产品简称 :
[BDNF]
产品名称同义词 :
[Brain-derived neurotrophic factor; BDNF; Abrineurin; BDNF]
其他名称 :
[brain-derived neurotrophic factor isoform a preproprotein; Brain-derived neurotrophic factor; brain-derived neurotrophic factor; brain-derived neurotrophic factor; Abrineurin]
产品基因名称 :
[BDNF]
其他基因名称 :
[BDNF;BDNF;ANON2;BULN2;BDNF]
UniProt数据库进入名 :
BDNF_HUMAN
克隆性 :
多克隆
抗体亚型 :
兔IgE
宿主 :
兔
反应物种 :
Human. Predicted Reactivity: Bovine, Horse, Mouse, Pig, Rat
序列位置 :
[206-236]
序列长度 :
247
特异性 :
This BDNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the C-terminal region of human BDNF.
纯度 :
纯化兔多克隆抗体(多克隆抗体)
形式 :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
储存稳定性 :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
检测过的应用 :
免疫印迹, 免疫组化-P, IF, FC, E
应用笔记 :
WB~~1:1000。 免疫组化-P~~1:10~50。 IF~~1:10~50。 FC~~1:10~50
image1头 :
试验数据(TD)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫荧光(IF)
image4头 :
流式细胞仪(FC/流式细胞仪)
image4描述 :
Flow cytometric analysis of CEM cells using BDNF Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
其它信息1 :
Function: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Cellular location: Secreted. Tissue location: Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expresed in heart, lung , skeletal muscle, testis, prostate and placenta.
产品种类 :
Cardiovascular; Metabolism; Neuroscience; Signal Transduction
产品描述 :
BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.
产品引用 :
Jiang,H., Clin. Chim. Acta 400 (1-2), 3-7 (2009). Liu,L., Psychiatr. Genet. 18 (6), 267-274 (2008). Dmitrzak-Weglarz,M., Pharmacogenomics 9 (11), 1595-1603 (2008)
NCBI GI登录号 :
219842288
NCBI登录号 :
NP_001137277.1
NCBI基因登录号 :
NM_001143805.1
UniProt数据库登录号 :
P23560
NCBI信号通路 :
通路(627);, 通路(627);, 通路(627);, 通路(627);, 通路(627);, 通路(627);, 通路(627);, 通路(627);, 通路(627);, 通路(627)
NCBI总结 :
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
UniProt数据库总结 :
BDNF: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Belongs to the NGF-beta family. 5 isoforms of the human protein are produced by alternative promoter. Protein type: Cytokine; Secreted; Cell development/differentiation; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: extracellular space; synaptic vesicle; mitochondrial crista; perinuclear region of cytoplasm; cytoplasm; dendrite; cytoplasmic membrane-bound vesicle; extracellular region; terminal button; perikaryon. Molecular Function: growth factor activity; neurotrophin TRKB receptor binding. Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; behavioral fear response; mitochondrial electron transport, NADH to ubiquinone; regulation of neuron differentiation; axon extension; response to hormone stimulus; positive regulation of long-term neuronal synaptic plasticity; response to vitamin A; negative regulation of neuroblast proliferation; ureteric bud development; dendrite development; regulation of retinal cell programmed cell death; feeding behavior; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; response to electrical stimulus; inner ear development; response to food; nervous system development; chronic inflammatory response; response to light intensity; neuron recognition; regulation of axon extension; learning; regulation of short-term neuronal synaptic plasticity; negative regulation of striated muscle development; positive regulation of peptidyl-serine phosphorylation; positive regulation of synaptogenesis; axon target recognition; response to hyperoxia; glutamate secretion; response to fluoxetine; response to hypoxia; nerve development; response to activity; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; gamma-aminobutyric acid signaling pathway. Disease: Obsessive-compulsive Disorder; Bulimia Nervosa, Susceptibility To, 1; Bulimia Nervosa, Susceptibility To, 2; Central Hypoventilation Syndrome, Congenital
尺寸1 :
0.08毫升
价格1 :
165美元
尺寸2 :
0.4毫升
价格2 :
370
更多信息或购买 :
公司信息
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MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。