产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
HSF1(磷酸化Ser307)抗体
目录 :
MBS857430
规格 :
0.1毫克
价格 :
215美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
产品信息
目录号 :
MBS857430
产品类型 :
抗体
产品全称 :
HSF1(磷酸化Ser307)抗体
产品简称 :
HSF1
其他名称 :
heat shock factor protein 1; Heat shock factor protein 1; heat shock factor protein 1; HSF 1; HSTF 1; heat shock transcription factor 1; Heat shock transcription factor 1; HSTF 1
产品基因名称 :
HSF1
其他基因名称 :
HSF1;HSF1;HSTF1;HSTF1;HSF 1;HSTF 1
UniProt数据库进入名 :
HSF1_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类
序列长度 :
529
特异性 :
HSF1 (Phospho-Ser307) Antibody detects endogenous levels of HSF1 only when phosphorylated at serine 307.
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度 :
50微克/50微升
储存稳定性 :
Store at -20 degree C for 1 year
检测过的应用 :
免疫印迹(免疫印迹), 免疫荧光(IF)
应用笔记 :
WB: 1:500~1:1000, IF: 1:100-200
其他信息2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human HSF1 around the phosphorylation site of serine 307 (P-Q-SP-P-R). Pathway: MAPK, Chromatin/Transcription
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品引用 :
Guettouche T, et al. (2005) BMC Biochem ; 6(1): 4. Wang X, et al. (2003) Mol Cell Biol ; 23(17): 6013-6026. Jolly C, et al. (1999) Proc Natl Acad Sci USA; 96(12): 6769-6774.
NCBI GI登录号 :
5031767
NCBI登录号 :
NP_005517.1
NCBI基因登录号 :
NM_005526.2
UniProt数据库登录号 :
Q00613
NCBI分子量 :
52,881 Da
NCBI信号通路 :
Attenuation Phase Pathway (980473); Cellular Response To Heat Stress Pathway (980470); Cellular Responses To Stress Pathway (645258); HSF1 Activation Pathway (980471); HSF1-dependent Transactivation Pathway (980472); Legionellosis Pathway (469200); Legionellosis Pathway (469186); Regulation Of HSF1-mediated Heat Shock Response Pathway (980474)
NCBI总结 :
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HSF1: a transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. Induced in response to heat, heavy metals, and oxidative stress. In higher eukaryotes, HSF is unable to bind to HSEs unless the cells are stressed. Becomes phosphorylated in response to stress, forming homotrimers that bind DNA and activate transcription. Phosphorylation by PLK1 enhances nuclear translocation, and phosphorylation by CaMKII enhances transactivation. Phosphorylation by GSK3 and ERK1 induces binding by 14-3-3 and sequestration in the cytoplasm. In addition, during attenuation from the heat shock response, HSF1 is repressed by direct binding of Hsp70, HSP40, and HSF binding protein 1 (HSBP1). Four alternatively spliced isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: nucleoplasm; protein complex; pronucleus; cytoplasm; cytosol. Molecular Function: protein binding; chromatin binding; transcription factor activity. Biological Process: embryonic placenta development; embryonic process involved in female pregnancy; female meiosis; defense response; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; positive regulation of multicellular organism growth; protein amino acid phosphorylation; negative regulation of cell proliferation; mRNA transcription; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis
尺寸1 :
0.1毫克
价格1 :
215美元
尺寸2 :
0.05毫克
价格2 :
225
更多信息或购买 :
公司信息
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MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。