抗体

真核生物肽起始因子4e(磷酸化Ser209)抗体

MBS857179

0.1毫克

215美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

真核生物肽起始因子4e(磷酸化Ser209)抗体

真核生物肽起始因子4e

eukaryotic translation initiation factor 4E isoform 3; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1; eukaryotic translation initiation factor 4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein

真核生物肽起始因子4e

真核生物肽起始因子4e;真核生物肽起始因子4e;CBP;真核生物肽起始因子4f;AUTS19;EIF4E1;EIF4EL1;EIF4EL1;真核生物肽起始因子4f;eIF-4E;真核生物肽起始因子4e

IF4E_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

237

elF4E (phospho-Ser209) antibody detects endogenous levels of elF4E only when phosphorylated at serine 209.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

液体

100微升, 0.45毫克/毫升

Store at -20 degree C for 1 year

免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF)

WB: 1:500~1:1000, IHC: 1:50~1:100

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human elF4E around the phosphorylation site of serine 209 (S-G-SP-T-T). Pathway: Akt, MAPK, Translation, Insulin/Glucose

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Li BD, et al. (1998) Ann Surg; 227(5): 756-763. Altmann M, et al. (1989) Nucleic Acids Res; 17(18): 7520. De Gregorio E, et al. (2001) RNA; 7(1): 106-113. Gu W, et al. (2004) Nucleic Acids Res; 32(15): 4448-4461

194578907

NP_001124150.1

NM_001130678.1

P06730

32-36kDa

Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway (105970); Alpha6-Beta4 Integrin Signaling Pathway (198807); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); BDNF Signaling Pathway (712093); Cap-dependent Translation Initiation Pathway (105967); Cytokine Signaling In Immune System Pathway (366171); Deadenylation Of MRNA Pathway (160994); Deadenylation-dependent MRNA Decay Pathway (160993); Eukaryotic Translation Initiation Pathway (105966); GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway (105973)

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Protein type: Translation initiation; Translation. Chromosomal Location of Human Ortholog: 4q23. Cellular Component: mRNA cap complex; stress granule; eukaryotic translation initiation factor 4F complex; cytoplasm; cytosol. Molecular Function: protein binding; eukaryotic initiation factor 4G binding; translation initiation factor activity; RNA cap binding. Biological Process: viral reproduction; translation; cytokine and chemokine mediated signaling pathway; positive regulation of mitotic cell cycle; regulation of translation; poly(A) tail shortening; mRNA export from nucleus; cellular protein metabolic process; insulin receptor signaling pathway; translational initiation; gene expression; G1/S transition of mitotic cell cycle; lung development; mRNA catabolic process, deadenylation-dependent decay. Disease: Autism, Susceptibility To, 19

0.1毫克

215美元

0.05毫克

225