产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
IGF-1R(Ab-1165/1166)抗体
目录 :
MBS856987
规格 :
0.05毫克
价格 :
180美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS856987
产品类型 :
抗体
产品全称 :
IGF-1R(Ab-1165/1166)抗体
产品简称 :
IGF-1R
其他名称 :
insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
产品基因名称 :
IGF-1R
其他基因名称 :
胰岛素样生长因子1受体;胰岛素样生长因子1受体;IGFR;CD221;IGFIR;JTK13;IGF-I受体
UniProt数据库进入名 :
IGF1R_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
1367
特异性 :
IGF-1R(Ab-1165/1166)抗体检测内生水平总数IGF-1R蛋白
纯度 :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
形式 :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
浓度 :
50微克/50微升
储存稳定性 :
Store at -20 degree C for 1 year
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
WB: 1:500~1:1000
其他信息2 :
Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human IGF-1R around the phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-YP-YP-R-K). Pathway: Receptors, Kinase/Phosphatases
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品引用 :
Li S, et al. (1994) J Biol Chem; 269(51): 32558-64.
NCBI GI登录号 :
4557665
NCBI登录号 :
NP_000866.1
NCBI基因登录号 :
NM_000875.4
UniProt数据库登录号 :
P08069
NCBI分子量 :
154,793 Da
NCBI信号通路 :
AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Apoptosis Pathway (198797); Endochondral Ossification Pathway (198812); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067)
NCBI总结 :
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt数据库总结 :
IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.1; TK group; InsR family. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: neuron projection; intracellular membrane-bound organelle; membrane; integral to plasma membrane; plasma membrane; caveola; receptor complex. Molecular Function: insulin binding; insulin-like growth factor binding; identical protein binding; protein binding; insulin-like growth factor I binding; insulin receptor substrate binding; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; G-protein alpha-subunit binding; insulin-like growth factor receptor activity; ATP binding; insulin receptor binding. Biological Process: epidermis development; phosphoinositide 3-kinase cascade; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; signal transduction; regulation of JNK cascade; response to vitamin E; positive regulation of MAPKKK cascade; mammary gland development; male sex determination; positive regulation of cell proliferation; protein tetramerization; positive regulation of cytokinesis; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; positive regulation of mitosis; negative regulation of transcription factor activity; positive regulation of protein kinase B signaling cascade; insulin-like growth factor receptor signaling pathway; axonogenesis; establishment of cell polarity; insulin receptor signaling pathway; immune response; brain development; positive regulation of DNA replication; positive regulation of cell migration; negative regulation of apoptosis. Disease: Insulin-like Growth Factor I, Resistance To
尺寸1 :
0.05毫克
价格1 :
180美元
尺寸2 :
0.1毫克
价格2 :
215
更多信息或购买 :
公司信息
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MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。