PDE3B抗体 | MyBioSource MBS840862 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

PDE3B抗体

MBS840862

规格 :

0.2毫克

价格 :

290美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠

应用 :

免疫印迹

更多信息或购买 :

MyBioSource 产品网页

产品信息

目录号 :

MBS840862

产品类型 :

抗体

产品全称 :

PDE3B抗体

产品简称 :

PDE3B

产品名称同义词 :

PDE3B;磷酸二酯酶类型3

其他名称 :

PDE3B protein; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; phosphodiesterase 3B, cGMP-inhibited; CGIPDE1; CGIP1; Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B

产品基因名称 :

PDE3B

其他基因名称 :

PDE3B;PDE3B;HcGIP1;cGIPDE1;CGIP1;CGI-PDE B

UniProt数据库进入名 :

PDE3B_HUMAN

克隆性 :

多克隆

抗体亚型 :

IgG

宿主 :

兔

反应物种 :

人类, 小鼠, 大鼠

序列长度 :

1061

纯度 :

亲和纯化

形式 :

200 ug (0.5 mg/ml) affinity purified rabbit anti-PDE3B polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. Appearance: Colorless liquid

储存稳定性 :

At -20 degree C for long term storage. Aliquot and freeze at -70 degree C. Avoid repeated freeze/thaw cycles

检测过的应用 :

免疫印迹(免疫印迹)

应用笔记 :

The antibody can be used for Western blotting (1-4 ug/ml). However, the optimal conditions should be determined individually, Blocking peptide (Catalod Number: MBS843957 is available separately.

其它信息1 :

Immunogen: Synthetic peptide surrounding amino acid 948 of mouse PDE3B. Positive Control: Jurkat, Rat kidney, 3T3 cell lysates

其他信息2 :

Handling: The antibody solution should be gently mixed before use.

产品种类 :

Antibodies & Supporting Tools; Primary Antibodies (A-Z)

产品描述 :

Background: The phosphodiesterase type-3 (PDE3) family is comprised of 2 isoforms, PDE3A and PDE3B.Phosphodiesterases (PDE) are crucial in the regulation of the intracellular level of the second messenger cAMP by hydrolyzing cAMP to 5'AMP. PDE3B has two splice variants that are expressed in adipocyte tissue, hepatocyte, kidney, spermatocytes and embryonic neuroepithelium. Both PDE3A and PDE3B are potential targets for the treatment of obesity.

NCBI GI登录号 :

219519624

NCBI登录号 :

AAI44249.1

NCBI分子量 :

118,809 Da

UniProt数据库总结 :

PDE3B: a cGMP-inhibited phosphodiesterase 1 involved in fat metabolism. Inhibition of PDE3B can augment PDE4 inhibitor-induced apoptosis in some patients with chronic lymphocytic leukemia. Protein type: Membrane protein, integral; Nucleotide Metabolism - purine; Membrane protein, multi-pass; EC 3.1.4.17; Phosphodiesterase. Chromosomal Location of Human Ortholog: 11p15.1. Cellular Component: Golgi apparatus; membrane; endoplasmic reticulum; integral to membrane; cytosol. Molecular Function: protein kinase B binding; protein binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; 3 ,5 -cyclic-nucleotide phosphodiesterase activity. Biological Process: negative regulation of angiogenesis; cellular response to insulin stimulus; negative regulation of lipid catabolic process; cAMP catabolic process; insulin receptor signaling pathway; negative regulation of cell adhesion; angiogenesis; blood coagulation; glucose homeostasis; regulation of insulin secretion; negative regulation of cell adhesion mediated by integrin; endocrine pancreas development

尺寸1 :

0.2毫克

价格1 :

290美元

更多信息或购买 :

MyBioSource 产品网页

公司信息