ELISA/assay

Human Heat Shock Factor 1 ELISA Kit

MBS722401

48-Strip-Wells-(Comp

470美元

酶联免疫吸附试剂盒

Human Heat Shock Factor 1 ELISA Kit

Heat Shock Factor 1

heat shock factor protein 1; Heat shock factor protein 1; heat shock factor protein 1; HSF 1; HSTF 1; heat shock transcription factor 1; Heat shock transcription factor 1; HSTF 1

HSF1

HSF1;HSF1;HSTF1;HSTF1;HSF 1;HSTF 1

HSF1_HUMAN

人类

Store all reagents at 2-8 degree C.

Assay Type: Competitive or Sandwich

Highest Standards: 10ng/mL. Concentration of Standards: Concentration of Standards: 0,0.5,1.0,2.5,5.0,10ng/mL

信号转导

5031767

NP_005517.1

NM_005526.2

52,881 Da

Attenuation Phase Pathway (980473); Cellular Response To Heat Stress Pathway (980470); Cellular Responses To Stress Pathway (645258); HSF1 Activation Pathway (980471); HSF1-dependent Transactivation Pathway (980472); Legionellosis Pathway (469200); Legionellosis Pathway (469186); Regulation Of HSF1-mediated Heat Shock Response Pathway (980474)

The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]

HSF1: a transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. Induced in response to heat, heavy metals, and oxidative stress. In higher eukaryotes, HSF is unable to bind to HSEs unless the cells are stressed. Becomes phosphorylated in response to stress, forming homotrimers that bind DNA and activate transcription. Phosphorylation by PLK1 enhances nuclear translocation, and phosphorylation by CaMKII enhances transactivation. Phosphorylation by GSK3 and ERK1 induces binding by 14-3-3 and sequestration in the cytoplasm. In addition, during attenuation from the heat shock response, HSF1 is repressed by direct binding of Hsp70, HSP40, and HSF binding protein 1 (HSBP1). Four alternatively spliced isoforms have been described. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: nucleoplasm; protein complex; pronucleus; cytoplasm; cytosol. Molecular Function: protein binding; chromatin binding; transcription factor activity. Biological Process: embryonic placenta development; embryonic process involved in female pregnancy; female meiosis; defense response; response to lipopolysaccharide; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; negative regulation of cell proliferation; mRNA transcription; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis

48-Strip-Wells-(Competitive)

470美元

48-Strip-Wells-(Sandwich)

470

96-Strip-Wells-(Competitive)

675

96-Strip-Wells-(Sandwich)

675