抗体

兔抗人类电压依赖性阴离子通道2多克隆抗体

MBS714555

0.05毫升

375美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

兔抗人类电压依赖性阴离子通道2多克隆抗体

电压依赖性阴离子通道2

电压依赖性阴离子通道2;VDAC2;FLJ23841

Voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2; voltage-dependent anion-selective channel protein 2; outer mitochondrial membrane protein porin 2; voltage-dependent anion channel 2; Outer mitochondrial membrane protein porin 2

VDAC2;VDAC2;POR;VDAC-2;hVDAC2

VDAC2_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

294

抗原亲和纯化

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Immunogen: Human VDAC2

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

54035063

AAH12883.2

30,412 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Parkinson's Disease Pathway (83098); CGMP-PKG Signaling Pathway (983748); CGMP-PKG Signaling Pathway (985584)

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VDAC2: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, misc.; Mitochondrial; Membrane protein, integral. Chromosomal Location of Human Ortholog: 10q22. Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; nucleus. Molecular Function: protein binding; nucleotide binding; voltage-gated anion channel activity; porin activity. Biological Process: negative regulation of protein polymerization; transmembrane transport; anion transport

0.05毫升

375美元

0.15毫升

715