抗体

A-20/TNFAIP3,Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)

MBS668220

0.1毫克

290美元

单克隆

小鼠

未共轭

[ABM1G20]

免疫印迹, 流式细胞仪

抗体

A-20/TNFAIP3,Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)

[A-20/TNFAIP3]

[TNFAIP3, OTUD7C]

[tumor necrosis factor alpha-induced protein 3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3; TNF alpha induced protein 3; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20]

[TNFAIP3]

[TNFAIP3; TNFAIP3; A20; AISBL; OTUD7C; TNFA1P2; OTUD7C; TNF alpha-induced protein 3]

TNAP3_HUMAN

单克隆

IgG1, Kappa

[ABM1G20]

小鼠

人类

790

Protein G choromatography

Purified. 25 ug in 50 uL/ 100 ug in 200 uL PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

流式细胞仪, 免疫印迹

Western Blot: 4-6 ug/mL

免疫印迹(免疫印迹)

流式细胞仪(FC)

Immunogen: A partial length recombinant protein from C terminal portion of A20 was used as the immunogen for this antibody. Buffer: PBS containing 0.05% BSA and 0.05% sodium azide.

Target Modification: No. Produced from Ascites: No

Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)

395393995

NP_001257436.1

NM_001270507.1

P21580

CD40/CD40L Signaling Pathway (138061); Canonical NF-kappaB Pathway (138030); Death Receptor Signalling Pathway (1269644); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Measles Pathway (213306); Measles Pathway (213277); NF-kappa B Signaling Pathway (634527)

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

TNFAIP3: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax. By TNF. Belongs to the peptidase C64 family. Protein type: Apoptosis; Protease; EC 3.4.19.12; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 6q23. Cellular Component: cytoplasm; cytosol; lysosome; nucleus. Molecular Function: DNA binding; kinase binding; ligase activity; protease binding; protein binding; protein self-association; ubiquitin binding; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding. Biological Process: apoptosis; B-1 B cell homeostasis; inflammatory response; inhibition of NF-kappaB transcription factor; negative regulation of B cell activation; negative regulation of bone resorption; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein kinase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interferon type I production; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of protein catabolic process; protein deubiquitination; protein oligomerization; regulation of defense response to virus by host; regulation of germinal center formation; regulation of inflammatory response; response to molecule of bacterial origin; response to muramyl dipeptide

0.1毫克

290美元