产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
A-20/TNFAIP3,Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)
目录 :
MBS668220
规格 :
0.1毫克
价格 :
290美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
[ABM1G20]
反应物种 :
人类
应用 :
免疫印迹, 流式细胞仪
更多信息或购买 :
图像
图像 1 :
![MyBioSource MBS668220 图像 1](http://www.labome.com/product/MyBioSource/6059591_0.jpg)
Expression analysis of A20. Anti-A20 antibody (Clone: ABM1G20) was tested at 4 ug/ml on THP-1 Lysate.
图像 2 :
![MyBioSource MBS668220 图像 2](http://www.labome.com/product/MyBioSource/6059591_1.jpg)
Cell surface FLOW analysis of A20 (Clone : ABM1G20) on HepG2 cells using 0.5 ug/10^6 cells of antibody. Goat anti-mouse PE conjugate was used as secondary antibody. Green represents isotope control , red represents anti-A20 antibody
产品信息
目录号 :
MBS668220
产品类型 :
抗体
产品全称 :
A-20/TNFAIP3,Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)
产品简称 :
[A-20/TNFAIP3]
产品名称同义词 :
[TNFAIP3, OTUD7C]
其他名称 :
[tumor necrosis factor alpha-induced protein 3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3; TNF alpha induced protein 3; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20]
产品基因名称 :
[TNFAIP3]
其他基因名称 :
[TNFAIP3; TNFAIP3; A20; AISBL; OTUD7C; TNFA1P2; OTUD7C; TNF alpha-induced protein 3]
UniProt数据库进入名 :
TNAP3_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1, Kappa
克隆 :
[ABM1G20]
宿主 :
小鼠
反应物种 :
人类
序列长度 :
790
纯度 :
Protein G choromatography
形式 :
Purified. 25 ug in 50 uL/ 100 ug in 200 uL PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
储存稳定性 :
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
检测过的应用 :
流式细胞仪, 免疫印迹
应用笔记 :
Western Blot: 4-6 ug/mL
image1头 :
免疫印迹(免疫印迹)
image2头 :
流式细胞仪(FC)
其它信息1 :
Immunogen: A partial length recombinant protein from C terminal portion of A20 was used as the immunogen for this antibody. Buffer: PBS containing 0.05% BSA and 0.05% sodium azide.
其他信息2 :
Target Modification: No. Produced from Ascites: No
产品描述 :
Monoclonal antibody to A-20/TNFAIP3 (Clone: ABM1G20)
NCBI GI登录号 :
395393995
NCBI登录号 :
NP_001257436.1
NCBI基因登录号 :
NM_001270507.1
UniProt数据库登录号 :
P21580
NCBI信号通路 :
CD40/CD40L Signaling Pathway (138061); Canonical NF-kappaB Pathway (138030); Death Receptor Signalling Pathway (1269644); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Measles Pathway (213306); Measles Pathway (213277); NF-kappa B Signaling Pathway (634527)
NCBI总结 :
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
UniProt数据库总结 :
TNFAIP3: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax. By TNF. Belongs to the peptidase C64 family. Protein type: Apoptosis; Protease; EC 3.4.19.12; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 6q23. Cellular Component: cytoplasm; cytosol; lysosome; nucleus. Molecular Function: DNA binding; kinase binding; ligase activity; protease binding; protein binding; protein self-association; ubiquitin binding; ubiquitin-protein ligase activity; ubiquitin-specific protease activity; zinc ion binding. Biological Process: apoptosis; B-1 B cell homeostasis; inflammatory response; inhibition of NF-kappaB transcription factor; negative regulation of B cell activation; negative regulation of bone resorption; negative regulation of chronic inflammatory response; negative regulation of cyclin-dependent protein kinase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of innate immune response; negative regulation of interferon type I production; negative regulation of interleukin-1 beta production; negative regulation of interleukin-2 production; negative regulation of interleukin-6 production; negative regulation of protein ubiquitination; negative regulation of smooth muscle cell proliferation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 3 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 5 signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of protein catabolic process; protein deubiquitination; protein oligomerization; regulation of defense response to virus by host; regulation of germinal center formation; regulation of inflammatory response; response to molecule of bacterial origin; response to muramyl dipeptide
尺寸1 :
0.1毫克
价格1 :
290美元
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/977.gif)
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。
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