产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
磷脂酶C, 丙2, 磷酸化(Tyr1217)
目录 :
MBS626427
规格 :
0.1毫克
价格 :
520美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫组化
更多信息或购买 :
图像
图像 1 :
![MyBioSource MBS626427 图像 1](http://www.labome.com/product/MyBioSource/6059370_0.jpg)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MBS626427.
产品信息
目录号 :
MBS626427
产品类型 :
抗体
产品全称 :
磷脂酶C, 丙2, 磷酸化(Tyr1217)
产品简称 :
[磷脂酶C, 丙2]
产品名称同义词 :
[Anti -Phospholipase C, gamma 2, phosphorylated (Tyr1217)]
其他名称 :
[phospholipase C, gamma 2 (phosphatidylinositol-specific), isoform CRA_a; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; PLC-IV; PLC-gamma-2; phospholipase C-IV; phospholipase C gamma 2; phospholipase C-gamma-2; phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2 (phosphatidylyinositol-specific); phospholipase C, gamma 2 (phosphatidylinositol-specific); Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2]
其他基因名称 :
[PLCG2;PLCG2]
UniProt数据库进入名 :
PLCG2_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类
特异性 :
Recognizes endogenous levels of human PLC-gamma 2 only when phosphorylated at tyrosine 1217.
纯度 :
亲和纯化。 经免疫亲和层析纯化
形式 :
Supplied as a liquid in PBS, (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
浓度 :
1毫克/毫升
储存稳定性 :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
检测过的应用 :
免疫组化(免疫组化)
应用笔记 :
Suitable for use in Immunohistochemistry. Dilution: Immunohistochemistry (Paraffin sections): 1:50-1:100
image1头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: Synthesized phosphopeptide derived from human PLC-gamma2 around the phosphorylation site of tyrosine 1217 (F-L-pY-D-T).
产品种类 :
Antibodies; Abs to Enzymes, Phospholipase
产品描述 :
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. The phospholipase C gamma-2 (PLCgII) is an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate. PLCgII has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLCgII. Btk-deficient B cells exhibited a marked reduction in phosphorylation of the Src homology 2 (SH2)-SH3 linker region sites, Tyr(753) and Tyr(759). Phosphorylation of both sites was restored by expression of Tec, but not Syk, family kinases. In contrast, phosphorylation of the PLCgamma2 carboxyl-terminal sites, Tyr(1197) and Tyr(1217), was unaffected by the absence of functional Btk.
NCBI GI登录号 :
119615931
UniProt数据库登录号 :
P16885
NCBI分子量 :
147,870 Da
NCBI信号通路 :
B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class I PI3K Signaling Events Pathway (138022); D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway (138940); D-myo-inositol-5-phosphate Metabolism Pathway (138601); EGFR1 Signaling Pathway (198782)
NCBI总结 :
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM]
UniProt数据库总结 :
PLCG2: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Protein type: Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16q24.1. Cellular Component: plasma membrane; cytosol. Molecular Function: signal transducer activity; protein binding; phospholipase C activity; phosphoinositide phospholipase C activity. Biological Process: platelet activation; inositol phosphate metabolic process; Wnt receptor signaling pathway; phospholipid catabolic process; calcium-mediated signaling; response to lipopolysaccharide; T cell receptor signaling pathway; activation of store-operated calcium channel activity; B cell receptor signaling pathway; inositol trisphosphate biosynthetic process; regulation of gene expression; release of sequestered calcium ion into cytosol; B cell differentiation; phosphatidylinositol biosynthetic process; negative regulation of programmed cell death; innate immune response; follicular B cell differentiation; blood coagulation. Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3
尺寸1 :
0.1毫克
价格1 :
520美元
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/977.gif)
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。
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