抗体

Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, Cytidine Aminohydrolase, HIGM2, Integrated into Burkitt's Lymphoma Cell Line Ramos)

MBS605724

0.1毫升

550美元

单克隆

unidentified

未共轭

[10g133]

人类, 小鼠

抗体

Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, Cytidine Aminohydrolase, HIGM2, Integrated into Burkitt's Lymphoma Cell Line Ramos)

[Activation-induced Cytidine Deaminase]

[Anti -Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, Cytidine Aminohydrolase, HIGM2, Integrated into Burkitt's Lymphoma Cell Line Ramos)]

[activation-induced cytidine deaminase; AID; activation-induced cytidine deaminase; OTTHUMP00000239182; OTTHUMP00000239185; OTTHUMP00000239186; cytidine aminohydrolase; integrated into Burkitt's lymphoma cell line Ramos; activation-induced cytidine deaminase]

[AICDA;AID;AID;ARP2;CDA2;HIGM2;AICDA]

Q546Y9_HUMAN

单克隆

IgG1

[10g133]

未知

小鼠

Recognizes endogenous levels of human AID protein.

腹水

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, < 0.02% sodium azide, 50% glycerol.

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)。 其他未被检测的应用

Western Blot: 1:1000. Immunoprecipitation: 1:50. Optimal dilutions to be determined by the researcher.

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)

Immunogen: Synthetic peptide corresponding to residues of human AID.

Antibodies; Abs to Enzymes

Activation-induced cytidine deaminase (AID) is thought to modify RNA due to its high homology to the RNA editing enzyme APOBEC-1. This function, however, has not been confirmed in in vitro studies, which show that AID has significant cytidine deaminase activity, and that this activity is blocked by zinc chelation. The B cell immune system must specifically recognize several infectious agents, which vastly outnumber immunoglobulin gene segments present in a given organism. Mechanisms such as somatic hypermutation, isotype switch recombination and gene conversion introduce diversity and specificity to the immune system. Analysis of mouse models and patients with AID deficiency has established a link between all three of these mechanisms and AID function. AID protein is detected in germinal center centroblast and germinal center derived lymphomas (Burkitt lymphoma), but not in pre-germinal center B cells or post-germinal center neoplasms (B cell chronic lymphocytic leukemia and multiple myeloma).

10190700

NP_065712.1

NM_020661.2

Q546Y9

IL4-mediated Signaling Events Pathway (137933); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq]

0.1毫升

550美元