抗体

Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2)

MBS6012549

0.1毫克

655美元

单克隆

小鼠

未共轭

[11n151]

免疫印迹, 免疫沉淀

抗体

Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2)

[Phospholipase A2, Secretory, Group IB]

[Anti -Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2)]

[phospholipase A2; Phospholipase A2; phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2, group IB (pancreas); Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B]

[PLA2G1B;PLA2G1B;PLA2;PLA2A;PPLA2;PLA2;PLA2A;PPLA2]

PA21B_HUMAN

单克隆

IgG2A

[11n151]

小鼠

人类

Recognizes human PLA2G1B. No cross-reactivity with recombinant human PLA2G2A, PLA2G7, recombinant mouse PLA2G2A, or PLA2R1.

Affinity Purified. Purified by Protein A/G affinity chromatography.

Supplied as a lyophilized powder in PBS, pH7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.

~0.5 mg/ml (after reconstitution)

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)

Suitable for use in Western Blot and Immunoprecipitation. Dilution: Western Blot: 2ug/ml. Immunoprecipitation: 25ug/ml

免疫印迹(免疫印迹)

Immunogen: Recombinant corresponding to aa1-148 from human PLA2G1B expressed in NSO cells (NM_000928).

Antibodies; Abs to Enzymes, Phospholipase

PLA2G1B, hydrolyses the sn-2 ester bond of phospholipids, including those in cell membranes, to generate non-esterified free fatty acids and lysophospholipids. Most secretory PLA2s are stored in cytoplasmic granules and are released into plasma and biological fluids on appropriate cell activation, especially during systemic inflammatory, autoimmune, or allergic disease. PLA2G1B is abundant in digestive organs but is also found elsewhere. Human PLA2G1B shares 78-76aa sequence identity with mouse and rat PLA2G1B, respectively.

4505847

NP_000919.1

NM_000928.2

P04054

16,360 Da

Acyl Chain Remodelling Of PC Pathway (645321); Acyl Chain Remodelling Of PE Pathway (645317); Acyl Chain Remodelling Of PG Pathway (645328); Acyl Chain Remodelling Of PI Pathway (645326); Acyl Chain Remodelling Of PS Pathway (645324); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (366); Ether Lipid Metabolism Pathway (82990); Ether Lipid Metabolism Pathway (365); Fat Digestion And Absorption Pathway (194385)

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

PLA2G1B: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family. Protein type: Lipid Metabolism - linoleic acid; Secreted, signal peptide; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Secreted; Phospholipase; DNA replication; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - arachidonic acid. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: extracellular space; cell surface; extracellular region; secretory granule. Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; bile acid binding; calcium ion binding; receptor binding. Biological Process: positive regulation of immune response; activation of MAPK activity; neutrophil mediated immunity; activation of phospholipase A2; glucose transport; signal transduction; phosphatidylcholine metabolic process; activation of NF-kappaB transcription factor; positive regulation of fibroblast proliferation; phospholipid metabolic process; fatty acid biosynthetic process; multicellular organismal lipid catabolic process; neutrophil chemotaxis; glycerophospholipid biosynthetic process; actin filament organization; arachidonic acid secretion; leukotriene biosynthetic process; defense response to Gram-positive bacterium; positive regulation of protein secretion; innate immune response in mucosa; cellular response to insulin stimulus; antibacterial humoral response; phosphatidic acid biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; interleukin-8 production; positive regulation of DNA replication

0.1毫克

655美元