产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Complement C3, C3c (Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1) (Biotin)
目录 :
MBS6003125
规格 :
1毫升
价格 :
600美元
克隆性 :
多克隆
宿主 :
unidentified
共轭标签 :
生物素
反应物种 :
人类, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法, dot blot
更多信息或购买 :
产品信息
目录号 :
MBS6003125
产品类型 :
抗体
产品全称 :
Complement C3, C3c (Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1) (Biotin)
产品简称 :
[补体C3, C3c]
产品名称同义词 :
[Anti -Complement C3, C3c (Complement Component C3c, C3/C3c, Acylation Stimulating Protein Cleavage Product, ASP, Complement Component 3, Complement Factor 3, CPAMD1) (Biotin)]
其他名称 :
[complement C3 preproprotein; Complement C3; complement C3; complement component 3<; C3adesArg]
其他基因名称 :
[C3;C3;ASP]
UniProt数据库进入名 :
CO3_BOVIN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
未知
反应物种 :
人类
特异性 :
Recognizes human C3c. In IEP against fresh human serum, a single precipitin line is obtained in the beta-1 region representing native C3. Against serum containing partly activated C3, a precipitin line is obtained which extends from the beta-1 into the alpha-2 region, demonstrating a gradient. In old serum containing totally activated C3 a single precipitin line in the alpha-2 region is obtained. Can also react with the fragments C3b, C3bi and smaller fragments, since they all carry antigenic determinants of the C3c domain. Does not react with any other proteins component of human serum or plasma.
纯度 :
纯化
形式 :
Supplied as a lyophilized powder from PBS, pH 7.2. Preservative free. Labeled with Biotin. Reconstitute with 1ml sterile ddH2O. Dilute further in PBS, pH 7.2.
储存稳定性 :
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
检测过的应用 :
ELISA (EL/EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Dot Blot (DB), Western Blot (WB),
应用笔记 :
Optimal dilution to be determined by the researcher.
其它信息1 :
Immunogen: C3c isolated and purified from pooled normal human serum.
其他信息2 :
Grade: Purified. Biotim/IgG protein molar ratio (B/P): ~7.1
产品种类 :
Antibodies; Abs to Complement
产品描述 :
C3c is the major fragment resulting from C3 cleavage by C3 convertase and factor I. It is composed of an intact beta chain bound to two fragments of the alpha chain. Locally deposited immune complexes in tissue usually contain complement, pointing to activation of the classical pathway. Complement activation in vivo implies active disease and may contribute to the elicitation of the pathogenesis and the extent of tissue destruction.
NCBI GI登录号 :
99028969
NCBI登录号 :
NP_001035559.2
NCBI基因登录号 :
NM_001040469.2
UniProt数据库登录号 :
Q2UVX4
NCBI分子量 :
187,253 Da
NCBI信号通路 :
Activation Of C3 And C5 Pathway (827281); Adaptive Immune System Pathway (827212); Alternative Complement Activation Pathway (827279); Chagas Disease (American Trypanosomiasis) Pathway (147808); Chagas Disease (American Trypanosomiasis) Pathway (147795); Class A/1 (Rhodopsin-like Receptors) Pathway (826961); Complement And Coagulation Cascades Pathway (84312); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (827274); G Alpha (i) Signalling Events Pathway (826991)
UniProt数据库总结 :
Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates . By similarity.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes . By similarity.Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-internalization and recycling of C5AR2 . By similarity. Subunit structure: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77 . By similarity. Interacts with BHV-1 glycoprotein C. Ref.3. Subcellular location: Secreted. Post-translational modification: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by dietary chylomicrons . By similarity.Phosphorylation sites are present in the extracellular medium . By similarity. Sequence similarities: Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain.
尺寸1 :
1毫升
价格1 :
600美元
更多信息或购买 :
公司信息
![logo](http://aws.labome.com/img/977.gif)
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。
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