抗体

亲和纯化山羊抗人类SAA抗体

MBS560674

0.1毫克

265美元

多克隆

山羊

未共轭

抗体

亲和纯化山羊抗人类SAA抗体

SAA(血清淀粉样蛋白A)

亲和纯化山羊抗人类SAA;抗人类SAA(血清淀粉样蛋白A)

血清淀粉样蛋白A;血清淀粉样蛋白A

血清淀粉样蛋白A蛋白;SAA

多克隆

山羊

人类

未共轭A.P

液体

1毫克/毫升

Store at 4 degree C. Shelf Life: 24 months after shipping date

This product is monospecific to Human SAA by immunoelectrophoresis and gel diffusion techniques. Suitable for blotting and ELISA applications

Buffer: Phosphate buffered saline, pH 7.2

Preservative: 0.1% sodium azide. Procedure: Goats were immunized with highly purified recombinant Human SAA. Antiserum was collected and immunoaffinity purified off an antigen containing immunoabsorbant. Cellular Location: Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, P-body. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. May also localize to the hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (By similarity) Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity). Tissue Location : Widely expressed.

人类蛋白

Goats were immunized with highly purified recombinant human SAA. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human SAA was immunoaffinity purified. Function: Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.

93352563

NP_001035288.1

NM_001040198.1

0.1毫克

265美元