抗体

磷酸甘油醛脱氢酶抗体

MBS534081

0.1毫升

180美元

多克隆

羊

未共轭

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

磷酸甘油醛脱氢酶抗体

磷酸甘油醛脱氢酶

多克隆磷酸甘油醛脱氢酶;抗磷酸甘油醛脱氢酶;磷酸甘油醛脱氢酶

glyceraldehyde-3-phosphate dehydrogenase isoform 1; Glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase GAPDH (EC:2.6.99.-)

磷酸甘油醛脱氢酶

磷酸甘油醛脱氢酶;磷酸甘油醛脱氢酶;G3PD;GAPD;HEL-S;GAPD;磷酸甘油醛脱氢酶

G3P_HUMAN

多克隆

羊

人类, 兔, 大肠杆菌

335

Purified IgG fraction supplied in PBS, pH 7.2 with 0.1% NaN3.

Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Biological Significance: Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an enzyme that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis, and ER to Golgi vesicle shuttling.

Biohazard Information: This product contains sodium azide (NaN3), a chemical highly toxic in pure form. At product concentrations, though not classified as hazardous, NaN3 may react with lead and copper plumbing to form highly explosive build-ups of metal azides. Upon disposal, flush with large volumes of water to prevent metal azide build-up in plumbing. Immunogen: GAPDH antibody was raised in sheep using a 12 amino acid synthetic peptide (HQVVSSDFNSDT) representing the most conserved region of human and rat GAPDH conjugated with KLH as the immunogen.

Proteases, Inhibitors, & Enzymes

羊多克隆磷酸甘油醛脱氢酶抗体

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms; Etsushi Kuroda, Ken J. Ishii, Satoshi Uematsu, Keiichi Ohata, Cevayir Coban, Shizuo Akira, Kosuke Aritake, Yoshihiro Urade, Yasuo Morimoto (Immunity: Volume: 34 Issue: 4 Page: 514-526 DOI: 10.1016/j.immuni.2011.03.019). The reduction of voluntary physical activity after poly I:C injection is independent of the effect of poly I:C-induced interferon-beta in mice; Takashi Matsumotoa, Hiroshi Takahashia, Daisuke Shivab, Noriaki Kawanishia, Michael J. Kremenika, Yasuko Katoc, Hiromi Yano (Physiology & Behavior: Volume: 93 Issue: 4-5 Page: 835-841 DOI: 10.1016/j.physbeh.2007.11.048). Calcineurin protects the heart in a murine model of dilated cardiomyopathy; Joerg Heinekea, b, Kai C. Wollertb, Hanna Osinskaa, Michelle A. Sargenta, Allen J. Yorka, Jeffrey Robbinsa, Jeffery D. Molkentin (Journal of Molecular and Cellular Cardiology: Volume: 48 Issue: 6 Page: 1080-1087 DOI: 10.1016/j.yjmcc.2009.10.012)

7669492

NP_002037.2

NM_002046.4

P04406

31,548 Da

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!Biosynthesis Of Antibiotics Pathway 1144997!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Gluconeogenesis Pathway 106204!!Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway 413342

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

0.1毫升

180美元