抗体

抗小鼠CD200, 纯化(克隆OX90)(大鼠IgG2a)

MBS520069

0.25毫克

280美元

单克隆

大鼠

未共轭

OX90

人类, 小鼠

酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

抗小鼠CD200, 纯化(克隆OX90)(大鼠IgG2a)

CD200

CD200, 纯化(克隆OX90)(大鼠IgG2a);抗小鼠CD200(OX2)单克隆抗体

CD200 antigen, isoform CRA_a; OX-2 membrane glycoprotein; OX-2 membrane glycoprotein; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal antibody MRC OX-2; CD200 molecule

CD200

CD200;CD200;MRC;MOX1;MOX2;OX-2;MOX1;MOX2

OX2G_HUMAN

单克隆

大鼠IGg2a

OX90

大鼠

小鼠

269

CD200(小鼠CD200(OX2))

纯化

Antibody Concentration: 0.1 mg/ml

For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin and FITC), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.

免疫组化(免疫组化), 酶联免疫吸附测定(EIA)

Immunogen: mouse CD200-rat CD4 fusion protein. Donor: Rat spleen. Fusion Partner: Y3 myeloma

Presentation: Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography). For maximum recovery of contents, spin down tube before use.

anti-mouse CD200 monoclonal antibody reacts with CD200 (OX2), a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, and brain tissue (neurons). CD200 consists of 2 immunoglobulin (Ig) domains, a Cterminus transmembrane domain and a small cytoplasmic domain (19 aa) which lacks signaling motifs. CD200 is the ligand for CD200 receptor (CD200R), which is very similar in structure to CD200 except that it has a larger cytoplasmic domain (67 aa), and its expression is restricted to myeloid-derived antigen presenting cells (APC's) and certain populations of T cells. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation. This clone is suitable for use in flow cytometry, immunohistochemistry (frozen sections) and ELISA.

119600082

EAW79676.1

P41217

31,264 Da

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Subunit structure: Interacts with CD200R1. Subcellular location: Cell membrane; Single-pass type I membrane protein. Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

0.25毫克

280美元