抗体

山羊抗TIM3/HAVCR2抗体

MBS421344

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 狗

免疫印迹, 酶免疫法

抗体

山羊抗TIM3/HAVCR2抗体

TIM3/HAVCR2

HAVCR2; TIM3; hepatitis A virus cellular receptor 2; FLJ14428; KIM-3; TIMD3; Tim-3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; kidney injury molecule-3; HAVCR2 antibody; TIM3 antibody; hepatitis A virus cellular receptor 2 antibody; FLJ14428 antibody; KIM-3 antibody; TIMD3 antibody; Tim-3 antibody; T cell immunoglobulin mucin 3 antibody; T cell immunoglobulin mucin-3 antibody; kidney injury molecule-3 antibody; TIM3 / HAVCR2

hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3

HAVCR2

TIM3

HAVCR2; HAVCR2; TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2; TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3

HAVR2_HUMAN

多克隆

山羊

Tested: Human; Expected from sequence similarity: Human, Dog

301

KWYSHSKEKIQN

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 35kDa band observed in Human Tonsil, Thymus, Lymph Node and Spleen lysates (calculated MW of 33.4kDa according to NP_116171.3). In transfected HEK293 transiently expressing HAVCR2 a band of approx.35kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.3-1. 0ug/ml.

Immunogen: Peptide with sequence C-KWYSHSKEKIQN, from the internal region of the protein sequence according to NP_116171.3. Epitope: Internal region

49574534

NP_116171.3

NM_032782.4

16,149 Da

Cytokine Signaling In Immune System Pathway (1269310); Immune System Pathway (1269170); Interleukin-2 Signaling Pathway (1269321); Signaling By Interleukins Pathway (1269318)

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q33.3. Cellular Component: cell junction; cell surface; early endosome; immunological synapse; integral to membrane. Molecular Function: metal ion binding. Biological Process: adaptive immune response; defense response to Gram-positive bacterium; inflammatory response; inhibition of NF-kappaB transcription factor; innate immune response; macrophage activation during immune response; maternal process involved in pregnancy; natural killer cell tolerance induction; negative regulation of interferon-alpha production; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of interleukin-3 production; negative regulation of interleukin-6 production; negative regulation of myeloid dendritic cell activation; negative regulation of natural killer cell activation; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of T cell proliferation; negative regulation of T-helper 1 type immune response; negative regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 production; positive regulation of interleukin-4 production; positive regulation of macrophage activation; positive regulation of T cell proliferation; regulation of tolerance induction dependent upon immune response; toll-like receptor 3 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway. Disease: Rheumatoid Arthritis

0.1毫克

300美元