抗体

山羊抗CGI58/ABHD5抗体

MBS421157

0.1毫克

300美元

多克隆

山羊

未共轭

人类, 小鼠, 大鼠, 狗, 牛

免疫印迹, 酶免疫法

抗体

山羊抗CGI58/ABHD5抗体

CGI58/ABHD5

ABHD5; CGI58 protein; aCGI58; bhydrolase domain containing 5; CDS; IECN2; MGC8731; NCIE2; ABHD5 antibody; CGI58 protein antibody; aCGI58 antibody; bhydrolase domain containing 5 antibody; CDS antibody; IECN2 antibody; MGC8731 antibody; NCIE2 antibody; CGI58 / ABHD5

1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain containing 5; Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58

ABHD5

CGI58

ABHD5;ABHD5;CDS;CGI58;IECN2;NCIE2;NCIE2

ABHD5_HUMAN

多克隆

山羊

Tested: Human. Mouse, Cow; Expected from sequence similarity: Human, Mouse, Rat, Dog

349

FPERPDLADQDR

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

肽ELISA:抗体检测限稀释1:16000

Immunogen: Peptide with sequence C-FPERPDLADQDR, from the internal region of the protein sequence according to NP_057090.2. Epitope: Internal region

Note: This antibody is not expected to cross-react with ABHD4.

31542303

NP_057090.2

NM_016006.4

39,096 Da

CDP-diacylglycerol Biosynthesis Pathway (142255); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (1270009); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Regulation Of Lipolysis In Adipocytes Pathway (1222950); Triacylglycerol Biosynthesis Pathway (142242)

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]

ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons. Protein type: Transferase; Lipase; EC 2.3.1.51. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particle; nucleus. Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophosphatidic acid acyltransferase activity; triacylglycerol lipase activity. Biological Process: cell differentiation; fatty acid metabolic process; phosphatidic acid biosynthetic process; positive regulation of lipoprotein lipase activity. Disease: Chanarin-dorfman Syndrome

0.1毫克

300美元