山羊抗SETMAR抗体 | MyBioSource MBS421149 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

山羊抗SETMAR抗体

MBS421149

规格 :

0.1毫克

价格 :

300美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

未共轭

反应物种 :

人类, 牛

应用 :

免疫印迹, 酶免疫法

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产品信息

目录号 :

MBS421149

产品类型 :

抗体

产品全称 :

山羊抗SETMAR抗体

产品简称 :

SETMAR

产品名称同义词 :

SETMAR; SET domain and mariner transposase fusion gene; METNASE; SET domain and mariner transposase fusion; SETMAR antibody; SET domain and mariner transposase fusion gene antibody; METNASE antibody; SET domain and mariner transposase fusion antibody

其他名称 :

histone-lysine N-methyltransferase SETMAR isoform 1; Histone-lysine N-methyltransferase SETMAR; histone-lysine N-methyltransferase SETMAR; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion protein

产品基因名称 :

SETMAR

其他基因名称 :

SETMAR; SETMAR; Mar1; METNASE; Metnase

UniProt数据库进入名 :

SETMR_HUMAN

克隆性 :

多克隆

宿主 :

山羊

反应物种 :

Tested: Human; Expected from sequence similarity: Human, Cow

序列长度 :

684

序列 :

RWQKCVDCNGSYFD

纯度 :

通过硫酸铵沉淀和用免疫多肽抗原亲和层析从山羊血清中纯化得到的

形式 :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

浓度 :

100ug specific antibody in 200ul

储存稳定性 :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

检测过的应用 :

肽酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

应用笔记 :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 70-75kDa band seen in Daudi lysate. Recommended for use at 1-3ug/ml.

其它信息1 :

Immunogen: Peptide with sequence RWQKCVDCNGSYFD, from the C Terminus of the protein sequence according to NP_006506.3. Epitope: C Terminus

NCBI GI登录号 :

194306650

NCBI登录号 :

NP_006506.3

NCBI基因登录号 :

NM_006515.3

NCBI分子量 :

62,124 Da

NCBI信号通路 :

Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320)

NCBI总结 :

This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

UniProt数据库总结 :

SETMAR: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43. Chromosomal Location of Human Ortholog: 3p26.1. Cellular Component: condensed chromosome; nucleus. Molecular Function: double-stranded DNA binding; endonuclease activity; histone lysine N-methyltransferase activity (H3-K36 specific); histone lysine N-methyltransferase activity (H3-K4 specific); protein binding; protein homodimerization activity; single-stranded DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; structure-specific DNA binding; zinc ion binding. Biological Process: cell proliferation; DNA catabolic process, endonucleolytic; DNA double-strand break processing; DNA integration; double-strand break repair via nonhomologous end joining; histone H3-K36 methylation; histone H3-K4 methylation; replication fork processing

尺寸1 :

0.1毫克

价格1 :

300美元

更多信息或购买 :

MyBioSource 产品网页

公司信息