产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
HLA-DPA1抗体
目录 :
MBS2529717
规格 :
0.06毫升
价格 :
195美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS2529717
产品类型 :
抗体
产品全称 :
HLA-DPA1抗体
产品简称 :
HLA-DPA1
产品名称同义词 :
DP(W3), DP(W4), HLA DP1A, HLA DPA1, HLA SB甲链, HLADP, HLADPA1
其他名称 :
HLA class II histocompatibility antigen, DP alpha 1 chain; HLA class II histocompatibility antigen, DP alpha 1 chain; HLA class II histocompatibility antigen, DP alpha 1 chain; HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II HLA-DPA1 antigen; MHC class II antigen; Primed lymphocyte test-1; major histocompatibility complex, class II, DP alpha 1; DP(W3); DP(W4); HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1
产品基因名称 :
HLA-DPA1
其他基因名称 :
HLA-DPA1;HLA-DPA1;PLT1;HLADP;HLASB;DP(W3);DP(W4);HLA-DP1A;HLA-DP1A;HLASB
UniProt数据库进入名 :
DPA1_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类
序列长度 :
260
纯度 :
抗原亲和纯化
储存稳定性 :
Store at -20 degree C. Avoid freeze / thaw cycles
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
WB: 1:500-1:5000
其它信息1 :
Immunogen: Fusion protein of HLA-DPA1. Calculated Molecular Weight: 60aa; 29kd. Observed Molecular Weight: 33kDa
其他信息2 :
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
NCBI GI登录号 :
335883187
NCBI登录号 :
NP_001229454.1
NCBI基因登录号 :
NM_001242525.1
NCBI分子量 :
29,381 Da
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)
NCBI总结 :
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HLA-DPA1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: Golgi membrane; cell surface; integral to plasma membrane; lysosomal membrane; plasma membrane; endosome membrane; trans-Golgi network membrane; MHC class II protein complex. Molecular Function: MHC class II receptor activity; peptide antigen binding. Biological Process: positive regulation of interferon-gamma production; cytokine and chemokine mediated signaling pathway; T cell costimulation; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell proliferation; immune response; positive regulation of T cell activation; T cell receptor signaling pathway
尺寸1 :
0.06毫升
价格1 :
195美元
尺寸2 :
0.12毫升
价格2 :
270
size3 :
0.2毫升
价格3 :
435
更多信息或购买 :
公司信息
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MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。