抗体

MAP3K12多克隆抗体

MBS2522510

0.06毫升

195美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

MAP3K12多克隆抗体

MAP3K12

DLK;MUK;ZPK;ZPKP1;MEKK12

MAP3K12 protein; Mitogen-activated protein kinase kinase kinase 12; mitogen-activated protein kinase kinase kinase 12; MAPK-upstream kinase; dual leucine zipper bearing kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; mixed lineage kinase; protein kinase MUK; mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; Leucine-zipper protein kinase; ZPK; MAPK-upstream kinase; MUK; Mixed lineage kinase

MAP3K12

MAP3K12;MAP3K12;DLK;MUK;ZPK;ZPKP1;MEKK12;ZPK;DLK;ZPK;MUK

M3K12_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

567

抗原亲和纯化

1.4毫克/毫升

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

酶联免疫吸附测定(EIA), 免疫组化(免疫组化)

IHC: 1:25-1:100

Background: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

29476775

AAH50050.1

Insulin Signaling Pathway (198845); MAPK (JNK) Signaling Pathway (1084764); MAPK (JNK) Signaling Pathway (1108227); MAPK (p38) Signaling Pathway (1084765); MAPK (p38) Signaling Pathway (1108228); MAPK Cascade Pathway (198834); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Regulation Of P38-alpha And P38-beta Pathway (137964)

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

DLK: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Protein type: Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; LZK subfamily. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: growth cone; membrane; axon; cytoplasm; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; MAP kinase kinase kinase activity; protein kinase binding; ATP binding; protein kinase activity. Biological Process: peptidyl-serine phosphorylation; activation of MAPKK activity; histone phosphorylation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; JNK cascade; protein amino acid phosphorylation

0.06毫升

195美元

0.12毫升

270

0.2毫升

435