山羊多克隆抗人类KDM2B/FBXL10 | MyBioSource MBS241985 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

山羊多克隆抗人类KDM2B/FBXL10

MBS241985

规格 :

0.05毫克

价格 :

495美元

克隆性 :

多克隆

宿主 :

山羊

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠, 狗, 鸡, 牛

应用 :

酶联免疫吸附测定, 免疫组化, 酶免疫法

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产品信息

目录号 :

MBS241985

产品类型 :

抗体

产品全称 :

山羊多克隆抗人类KDM2B/FBXL10

产品简称 :

KDM2B/FBXL10

产品名称同义词 :

Anti-KDM2B / FBXL10 Antibody (C-Terminus) IHC-plus; KDM2B; CXXC2; Fbl10; F-box/LRR-repeat protein 10; JHDM1B; F-box protein FBL10; FBXL10; Lysine-specific demethylase 2B; PCCX2; Protein JEMMA; Human KDM2B; FBXL10

其他名称 :

lysine-specific demethylase 2B isoform b; Lysine-specific demethylase 2B; lysine-specific demethylase 2B; F-box protein FBL10; F-box/LRR-repeat protein 10; CXXC-type zinc finger protein 2; protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B; F-box and leucine-rich repeat protein 10; jumonji C domain-containing histone demethylase 1B; jmjC domain-containing histone demethylation protein 1B; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; lysine (K)-specific demethylase 2B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B

产品基因名称 :

KDM2B

产品基因名称同义词 :

FBXL10

其他基因名称 :

KDM2B;KDM2B;CXXC2;Fbl10;PCCX2;FBXL10;JHDM1B;CXXC2;FBL10;FBXL10;JHDM1B;PCCX2;蛋白JEMMA

UniProt数据库进入名 :

KDM2B_HUMAN

克隆性 :

多克隆

宿主 :

山羊

反应物种 :

Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat

序列长度 :

1265

特异性 :

Human KDM2B / FBXL10. This antibody is expected to recognize isoform a (NP_115979.3) only.

纯度 :

Immunoaffinity Purified

形式 :

三羟甲基氨基甲烷缓冲盐液, pH值7.3, 0.5% BSA, 0.02% 叠氮化钠

浓度 :

0.5毫克/毫升

储存稳定性 :

Store at -20 degree C. Minimize freezing and thawing.

检测过的应用 :

免疫组化(免疫组化-石蜡), 酶联免疫吸附测定(EIA)

应用笔记 :

ELISA (1:32000), IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

其它信息1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-FGQVEEKLLQKLS from the C-terminus of human KDM2B / FBXL10 (NP_115979.3).

其他信息2 :

Immunogen Type: Synthetic peptide. Immunogen: KDM2B / FBXL10 antibody was raised against synthetic peptide C-FGQVEEKLLQKLS from the C-terminus of human KDM2B / FBXL10 (NP_115979.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Turkey, Chicken, Platypus (100%); Xenopus (85%). Antigen Modification: C-Terminus

产品种类 :

Family: F-Box

NCBI GI登录号 :

54112380

NCBI登录号 :

NP_001005366.1

NCBI基因登录号 :

NM_001005366.1

UniProt数据库登录号 :

Q8NHM5

NCBI分子量 :

144,769 Da

NCBI信号通路 :

Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); HDMs Demethylate Histones Pathway (1127685)

NCBI总结 :

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

UniProt数据库总结 :

FBXL10: Histone demethylase that demethylates Lys-4 and Lys- 36 of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 and dimethylated H3 Lys-36 residue while it has weak or no activity for mono- and tri-methylated H3 Lys-36 . Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.14.11.27; Oxidoreductase; Nucleolus; Demethylase; DNA-binding. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: nucleoplasm; nucleolus; PcG protein complex; nucleus. Molecular Function: rRNA binding; protein binding; histone demethylase activity; DNA binding; zinc ion binding; histone demethylase activity (H3-K36 specific). Biological Process: midbrain-hindbrain boundary morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; fourth ventricle development; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; midbrain development; forebrain development; spermatogenesis; embryonic camera-type eye morphogenesis; negative regulation of neuron apoptosis; lateral ventricle development; hindbrain development

尺寸1 :

0.05毫克

价格1 :

495美元

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