抗体

MOUSE抗蓖麻毒素A链

MBS216335

0.2毫克

390美元

单克隆

小鼠

未共轭

RA999

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

MOUSE抗蓖麻毒素A链

蓖麻毒素

Ricin; Ricin; Ricin precursor; rRNA N-glycosidase

RCOM_2159910

RICI_RICCO

单克隆

IgG1

RA999

小鼠

576

纯化。 纯化IgG-液体

IgG浓度1.0毫克/毫升

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Full length Ricin A (RCA60) from Ricinus communis. Buffer Solution: Phosphate buffered saline. Target Species: Plants

Mouse anti Ricin A Chain antibody, clone RA999 recognizes the A chain of the ricin toxin (RCA60), a 60kDa glycoprotein. Mouse anti Ricin A Chain antibody, clone RA999 also cross-reacts with RCA120. The ricin toxin consists of two chains, A and B, covalently linked by a disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essential for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A chain into the cell. Without the B chain, the A chain has very low toxicity.Ricin is easily extracted from the castor bean (Ricinus communis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, although a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for biological warfare although it is less stable than other agents, such as anthrax.

255588578

XP_002534649.1

XM_002534603.1

P02879

64,091 Da

0.2毫克

390美元