抗体

HRP-Linked Polyclonal Antibody to Thioredoxin (Trx)

MBS2046307

0.1毫克

255美元

多克隆

兔

HRP

人类, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

HRP-Linked Polyclonal Antibody to Thioredoxin (Trx)

[Thioredoxin (Trx)]

[TXN; ADF; SASP; TRDX; TRX1; ATL-derived factor; Surface-associated sulphydryl protein]

[硫氧还蛋白;硫氧还蛋白;硫氧还蛋白;硫氧还蛋白1]

[Trx]

[Txn1; Txn; Txn; Txn1; Trx]

多克隆

兔

人类

Antigen-specific Affinity Chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

200微克/毫升

Storage: Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

免疫印迹;免疫组化;免疫细胞化学

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user

Wetsern Blot

Source: Antibody labeling. Label: HRP. Traits: Liquid. Immunogen: Recombinant Thioredoxin (MET1~Val105) expressed in E.coli.

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2001389

16758644

NP_446252.1

NM_053800.3

Cellular Senescence Pathway (935708); Cellular Responses To Stress Pathway (935701); Detoxification Of Reactive Oxygen Species Pathway (935707); Immune System Pathway (936650); Inflammasomes Pathway (936724); Innate Immune System Pathway (936679); Metabolism Pathway (935443); Metabolism Of Nucleotides Pathway (935606); NFE2L2 Pathway (739005); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (936722)

protein-disulfide reductase enzyme that is important for redox signalling during apoptosis and cell growth [RGD, Feb 2006]

TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family. Protein type: Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 5q24. Cellular Component: axon; cell soma; cytoplasm; cytosol; dendrite; mitochondrion; nucleus. Molecular Function: enzyme binding; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; peptide disulfide oxidoreductase activity; protein disulfide oxidoreductase activity; protein-disulfide reductase activity; thioredoxin-disulfide reductase activity. Biological Process: cell redox homeostasis; negative regulation of protein export from nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding; positive regulation of peptidyl-serine phosphorylation; regulation of protein import into nucleus, translocation; response to activity; response to axon injury; response to drug; response to radiation; response to selenium ion

0.1毫克

255美元

0.2毫克

395

1毫克

935